1,1-dimethylethyl (3RS)-3-({2-(4-biphenylyl)-6-[(methylamino)carbonyl]-1H-benzimidazol-1-yl}methyl)-1-pyrrolidinecarboxylate

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Chemical Name:1,1-dimethylethyl (3RS)-3-({2-(4-biphenylyl)-6-[(methylamino)carbonyl]-1H-benzimidazol-1-yl}methyl)-1-pyrrolidinecarboxylate
CAS No.:1301189-91-2
Molecular Formula:C₃₁H₃₄N₄O₃
Molecular Weight:510.636
Hs Code.:

Synonyms:1,1-dimethylethyl (3RS)-3-({2-(4-biphenylyl)-6-[(methylamino)carbonyl]-1H-benzimidazol-1-yl}methyl)-1-pyrrolidinecarboxylate

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Chemical Property of 1,1-dimethylethyl (3RS)-3-({2-(4-biphenylyl)-6-[(methylamino)carbonyl]-1H-benzimidazol-1-yl}methyl)-1-pyrrolidinecarboxylate

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Technology Process of 1,1-dimethylethyl (3RS)-3-({2-(4-biphenylyl)-6-[(methylamino)carbonyl]-1H-benzimidazol-1-yl}methyl)-1-pyrrolidinecarboxylate

There total 7 articles about 1,1-dimethylethyl (3RS)-3-({2-(4-biphenylyl)-6-[(methylamino)carbonyl]-1H-benzimidazol-1-yl}methyl)-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1301189-89-8
2-(4-biphenylyl)-1-[((3R₅)-1-{[(1,1-dimethylethyl)oxy]carbonyl}-3-pyrrolidinyl)methyl]-1H-benzimidazole-6-carboxylic acid

: 74-89-5
methylamine

: 1301189-91-2
1,1-dimethylethyl (3RS)-3-({2-(4-biphenylyl)-6-[(methylamino)carbonyl]-1H-benzimidazol-1-yl}methyl)-1-pyrrolidinecarboxylate

Guidance literature:: 2-(4-biphenylyl)-1-[((3R₅)-1-{[(1,1-dimethylethyl)oxy]carbonyl}-3-pyrrolidinyl)methyl]-1H-benzimidazole-6-carboxylic acid; With dmap; diisopropyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 0.75h;

methylamine; In tetrahydrofuran; at 20 ℃; for 22h;

Reference yield:

: 93138-61-5
C-(1-benzyl-pyrrolidin-3-yl)-methylamine

: 1301189-91-2
1,1-dimethylethyl (3RS)-3-({2-(4-biphenylyl)-6-[(methylamino)carbonyl]-1H-benzimidazol-1-yl}methyl)-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 12 h / 0 - 20 °C

2.1: hydrogen / palladium(II) hydroxide; palladium 10% on activated carbon / acetic acid; methanol / 48 h / 20 °C

3.1: triethylamine / methanol / 24 h / 0 - 20 °C

4.1: sodium hydroxide; water / methanol / 3 h / 20 °C

5.1: dimethyl sulfoxide / 17 h / 98 °C / Inert atmosphere

6.1: sodium dithionite / ethanol; dimethyl sulfoxide / 23 h / 80 °C

7.1: dmap; diisopropyl-carbodiimide / tetrahydrofuran / 0.75 h / 20 °C

7.2: 22 h / 20 °C

With dmap; sodium dithionite; water; hydrogen; triethylamine; sodium hydroxide; diisopropyl-carbodiimide; palladium 10% on activated carbon; palladium(II) hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetic acid; dimethyl sulfoxide;

Reference yield:

: 849632-74-2
2,2,2-trifluoro-N-{[(3RS)-1-(phenylmethyl)-3-pyrrolidinyl]methyl}acetamide

: 1301189-91-2
1,1-dimethylethyl (3RS)-3-({2-(4-biphenylyl)-6-[(methylamino)carbonyl]-1H-benzimidazol-1-yl}methyl)-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium(II) hydroxide; palladium 10% on activated carbon / acetic acid; methanol / 48 h / 20 °C

2.1: triethylamine / methanol / 24 h / 0 - 20 °C

3.1: sodium hydroxide; water / methanol / 3 h / 20 °C

4.1: dimethyl sulfoxide / 17 h / 98 °C / Inert atmosphere

5.1: sodium dithionite / ethanol; dimethyl sulfoxide / 23 h / 80 °C

6.1: dmap; diisopropyl-carbodiimide / tetrahydrofuran / 0.75 h / 20 °C

6.2: 22 h / 20 °C

With dmap; sodium dithionite; water; hydrogen; triethylamine; sodium hydroxide; diisopropyl-carbodiimide; palladium 10% on activated carbon; palladium(II) hydroxide; In tetrahydrofuran; methanol; ethanol; acetic acid; dimethyl sulfoxide;