tert-butyl 4-(4-{5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-7H-pyrrolo[2,3-c]pyridazin-3-yl}-1H-pyrazol-1-yl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-{5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-7H-pyrrolo[2,3-c]pyridazin-3-yl}-1H-pyrazol-1-yl)piperidine-1-carboxylate
CAS No.:1349723-38-1
Molecular Formula:C₂₇H₂₉Cl₂FN₆O₃
Molecular Weight:575.47
Hs Code.:

Synonyms:tert-butyl 4-(4-{5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-7H-pyrrolo[2,3-c]pyridazin-3-yl}-1H-pyrazol-1-yl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-{5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-7H-pyrrolo[2,3-c]pyridazin-3-yl}-1H-pyrazol-1-yl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(4-{5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-7H-pyrrolo[2,3-c]pyridazin-3-yl}-1H-pyrazol-1-yl)piperidine-1-carboxylate

There total 9 articles about tert-butyl 4-(4-{5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-7H-pyrrolo[2,3-c]pyridazin-3-yl}-1H-pyrazol-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 178813-77-9
2,6-dichloro-3-fluorobenzaldehyde

: 1349723-42-7
tert-butyl 4-[4-(7H-pyrrolo[2,3-c]pyridazin-3-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate

: 1349723-38-1
tert-butyl 4-(4-{5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-7H-pyrrolo[2,3-c]pyridazin-3-yl}-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: With potassium hydroxide; at 110 ℃; for 16h; Sealed tube;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1349723-38-1
tert-butyl 4-(4-{5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-7H-pyrrolo[2,3-c]pyridazin-3-yl}-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 24 h / 100 °C

3: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

4: potassium hydroxide / 16 h / 110 °C / Sealed tube

With dmap; caesium carbonate; triethylamine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 877399-74-1
tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

: 1349723-38-1
tert-butyl 4-(4-{5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-7H-pyrrolo[2,3-c]pyridazin-3-yl}-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

2: potassium hydroxide / 16 h / 110 °C / Sealed tube

With caesium carbonate; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water;