1-benzyl-7-methylsulfanyl-3,4,5,6-tetrahydro-2H-azepinium iodide

Base Information

• Chemical Name: 1-benzyl-7-methylsulfanyl-3,4,5,6-tetrahydro-2H-azepinium iodide
• CAS No.: 1017237-89-6
• Molecular Formula: C₁₄H₂₀NS*I
• Molecular Weight: 361.29
• Mol file: 1017237-89-6.mol

Synonyms:1-benzyl-7-methylsulfanyl-3,4,5,6-tetrahydro-2H-azepinium iodide

Chemical Property of 1-benzyl-7-methylsulfanyl-3,4,5,6-tetrahydro-2H-azepinium iodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-7-methylsulfanyl-3,4,5,6-tetrahydro-2H-azepinium iodide

There total 4 articles about 1-benzyl-7-methylsulfanyl-3,4,5,6-tetrahydro-2H-azepinium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-benzylhexahydro-2H-azepine-2-thione (17642-90-9) + methyl iodide (74-88-4) → 1-benzyl-7-methylsulfanyl-3,4,5,6-tetrahydro-2H-azepinium iodide (1017237-89-6)

Guidance literature:

In nitromethane; at 20 ℃; Darkness;

DOI:10.1021/acs.joc.7b02150

Reference yield:

1-Benzyl-hexahydro-azepin-2-on (33241-96-2) → 1-benzyl-7-methylsulfanyl-3,4,5,6-tetrahydro-2H-azepinium iodide (1017237-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Lawessons reagent / dichloromethane / 20 °C / Inert atmosphere

2: tetrahydrofuran / 20 °C / Inert atmosphere

With Lawessons reagent; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.saa.2013.09.108

Reference yield:

benzyl bromide (100-39-0) → 1-benzyl-7-methylsulfanyl-3,4,5,6-tetrahydro-2H-azepinium iodide (1017237-89-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / Inert atmosphere

2: Lawessons reagent / dichloromethane / 20 °C / Inert atmosphere

3: tetrahydrofuran / 20 °C / Inert atmosphere

With Lawessons reagent; sodium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.saa.2013.09.108

upstream raw materials:

1-benzylhexahydro-2H-azepine-2-thione

methyl iodide

1-Benzyl-hexahydro-azepin-2-on

benzyl bromide

Downstream raw materials:

2,2-diallyl-1-benzylazepane

1-benzyl-2,2-dibutylazepane