1-(2-Chloroethoxy)naphthalene

Base Information

• Chemical Name: 1-(2-Chloroethoxy)naphthalene
• CAS No.: 51251-55-9
• Molecular Formula: C₁₂H₁₁ClO
• Molecular Weight: 206.672
• DSSTox Substance ID: DTXSID60457955
• Wikidata: Q82281050
• Mol file: 51251-55-9.mol

Synonyms:1-(2-chloroethoxy)naphthalene;51251-55-9;SCHEMBL1900320;DTXSID60457955;OEWZTQCGHOVCDF-UHFFFAOYSA-N;2-(napthalen-1-yloxy)-ethylchloride;2-(napthalen-1 -yloxy)-ethylchloride

Chemical Property of 1-(2-Chloroethoxy)naphthalene

Chemical Property:

• Melting Point: 28 °C
• Boiling Point: 202 °C(Press: 16 Torr)
• Density: 1.1993 g/cm3
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 206.0498427
• Heavy Atom Count: 14
• Complexity: 172

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Chloroethoxy)naphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC=C2OCCCl

Technology Process of 1-(2-Chloroethoxy)naphthalene

There total 6 articles about 1-(2-Chloroethoxy)naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

α-naphthol (90-15-3) + 2-chloro-ethanol (107-07-3) → 2-(naphthalen-1-yloxy)ethyl chloride (51251-55-9)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/jm0304010

Reference yield: 73.0%

→ 2-(naphthalen-1-yloxy)ethyl chloride (51251-55-9)

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃;

Reference yield:

2-(1-naphthyloxy)-1-ethanol (711-82-0) → 2-(naphthalen-1-yloxy)ethyl chloride (51251-55-9)

Guidance literature:

With pyridine; thionyl chloride;

upstream raw materials:

α-naphthol

2-chloroethyl tosylate

2-(1-naphthyloxy)-1-ethanol

1,2-bis-[1]naphthyloxy-ethane