(R)-3-((cyclopropylmethyl)sulfonyl)-2-(((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)amino)propanoic acid

Base Information

Chemical Name:(R)-3-((cyclopropylmethyl)sulfonyl)-2-(((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)amino)propanoic acid
CAS No.:849094-11-7
Molecular Formula:C₁₅H₁₇F₄NO₄S
Molecular Weight:383.364
Hs Code.:

Synonyms:(R)-3-((cyclopropylmethyl)sulfonyl)-2-(((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)amino)propanoic acid

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Chemical Property of (R)-3-((cyclopropylmethyl)sulfonyl)-2-(((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)amino)propanoic acid

Chemical Property:

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Technology Process of (R)-3-((cyclopropylmethyl)sulfonyl)-2-(((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)amino)propanoic acid

There total 5 articles about (R)-3-((cyclopropylmethyl)sulfonyl)-2-(((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)amino)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 849094-09-3
3-cyclopropylmethylsulfanyl-2(R)-[2,2,2-trifluoro-1(S)-(4-fluoro-phenyl)-ethylamino]propan-1-ol

: 849094-11-7
(R)-3-((cyclopropylmethyl)sulfonyl)-2-(((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)amino)propanoic acid

Guidance literature:: 3-cyclopropylmethylsulfanyl-2(R)-[2,2,2-trifluoro-1(S)-(4-fluoro-phenyl)-ethylamino]propan-1-ol; With chromium(VI) oxide; periodic acid; In acetonitrile; for 5h;

With potassium dihydrogenphosphate; In water; ethyl acetate;

Reference yield:

: 10213-10-2
sodium tungstate (VI) dihydrate

: methyl t-butylether

: 849094-18-4
(R)-3-((cyclopropylmethyl)thio)-2-(((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)amino)propanoic acid

: 1779-48-2
phenylphosphinic acid

: 32503-27-8
tetra(n-butyl)ammonium hydrogensulfate

: 849094-11-7
(R)-3-((cyclopropylmethyl)sulfonyl)-2-(((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)amino)propanoic acid

Guidance literature:: With dihydrogen peroxide; In hexane; ethyl acetate; toluene;

Reference yield:

: (R)-methyl2-amino-3-((cyclopropylmethyl)thio)propanoate hydrochloride

: 849094-11-7
(R)-3-((cyclopropylmethyl)sulfonyl)-2-(((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)amino)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / isopropyl alcohol; acetonitrile

2: hydrogenchloride / zinc(II) chloride / 1,2-dimethoxyethane; acetonitrile; lithium borohydride

3: dihydrogen peroxide / ethyl acetate; toluene; hexane

With hydrogenchloride; dihydrogen peroxide; potassium carbonate; zinc(II) chloride; In 1,2-dimethoxyethane; lithium borohydride; hexane; ethyl acetate; isopropyl alcohol; toluene; acetonitrile;