VBY-825

Base Information

Chemical Name:VBY-825
CAS No.:1310340-58-9
Molecular Formula:C₂₃H₂₉F₄N₃O₅S
Molecular Weight:535.56
Hs Code.:

Synonyms:(S)-N-cyclopropyl-3-((R)-3-(cyclopropylmethylsulfonyl)-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)propanamido)-2-oxopentanamide

Suppliers and Price of VBY-825

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
VBY-825
0.5mg
$ 150.00

ChemScene
VBY-825 99.84%
10mg
$ 1450.00

ChemScene
VBY-825 99.84%
5mg
$ 850.00

Total 12 raw suppliers

Chemical Property of VBY-825

Chemical Property:

PKA:11.83±0.20(Predicted)
Density:1.39±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

VBY-825 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses VBY-825 is a novel, reversible cathepsin inhibitor which has high potency against cathepsins B, L, S and V. VBY-825 is also a new and effective anti-tumor drug.

Technology Process of VBY-825

There total 6 articles about VBY-825 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1408001-11-5
(3S)-N-cyclopropyl-3-((R)-3-((cyclopropylmethyl)sulfonyl)-2-(((S)-2,2,2-trifluoro-1-(4-fluorophenyl)-ethyl)amino)propanamido)-2-hydroxypentanamide

: 144-55-8
sodium hydrogencarbonate

: sodium thiosulfate

: 1310340-58-9
(S)-N-cyclopropyl-3-((R)-3-(cyclopropylmethylsulfonyl)-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)propanamido)-2-oxopentanamide

Guidance literature:: With sodium chloride; In hexane; dichloromethane; water; ethyl acetate; acetonitrile;

Reference yield:

: (R)-methyl2-amino-3-((cyclopropylmethyl)thio)propanoate hydrochloride

: 1310340-58-9
(S)-N-cyclopropyl-3-((R)-3-(cyclopropylmethylsulfonyl)-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)propanamido)-2-oxopentanamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / isopropyl alcohol; acetonitrile

2: hydrogenchloride / zinc(II) chloride / 1,2-dimethoxyethane; acetonitrile; lithium borohydride

3: dihydrogen peroxide / ethyl acetate; toluene; hexane

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide; hexane; diethyl ether

5: sodium chloride / dichloromethane; ethyl acetate; hexane; acetonitrile; water

With hydrogenchloride; sodium chloride; dihydrogen peroxide; potassium carbonate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; zinc(II) chloride; In 1,2-dimethoxyethane; lithium borohydride; diethyl ether; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

: 1408001-09-1
potassium (R,Z)-3-((cyclopropylmethyl)thio)-2-((2,2,2-trifluoro-1-(4-fluorophenyl)ethylidene)-amino)propanoate

: 1310340-58-9
(S)-N-cyclopropyl-3-((R)-3-(cyclopropylmethylsulfonyl)-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)propanamido)-2-oxopentanamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / zinc(II) chloride / 1,2-dimethoxyethane; acetonitrile; lithium borohydride

2: dihydrogen peroxide / ethyl acetate; toluene; hexane

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide; hexane; diethyl ether

4: sodium chloride / dichloromethane; ethyl acetate; hexane; acetonitrile; water

With hydrogenchloride; sodium chloride; dihydrogen peroxide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; zinc(II) chloride; In 1,2-dimethoxyethane; lithium borohydride; diethyl ether; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;