Cizolirtine

Base Information

• Chemical Name: Cizolirtine
• CAS No.: 142155-43-9
• Molecular Formula: C₁₅H₂₁N₃O
• Molecular Weight: 259.351

Synonyms:(?à)-5-[a-[2-(Dimethylamino)ethoxy]benzyl]-1-methyl-1H-pyrazole;(?à)-5-[a-[2-(Dimethylamino)ethoxy]benzyl]-1-methylpyrazole;2-[(1-Methyl-1H-pyrazol-5-yl)(phenyl)methoxy]-N,N-dimethylethanamine;Cizolirtine

Chemical Property of Cizolirtine

Chemical Property:

• Vapor Pressure: 1.51E-05mmHg at 25°C
• Boiling Point: 366°Cat760mmHg
• Flash Point: 175.2°C
• PSA: 30.29000
• Density: 1.04g/cm³
• LogP: 2.08770

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cizolirtine

There total 7 articles about Cizolirtine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(N,N-dimethylamino)ethanol hydrochloride (2498-25-1) + (R)-(+)-1-Methyl-α-phenyl-1H-pyrazole-5-methanol (148408-72-4) → (R)-(+)-Cizolirtine (148981-62-8,142155-43-9)

Guidance literature:

With sodium hydroxide; water; tribenzylamine hydrochloride; In toluene; for 10h; Heating;

DOI:10.1055/s-1999-2712

Reference yield: 16.0%

(2-chloroethyl)dimethylamine hydrochloride (4584-46-7) + 1-methyl-5-(1'-hydroxy-1'phenylmethyl)pyrazole (32500-65-5) → 2-[phenyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimethylethanamine (142155-43-9)

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In toluene; for 16h; Reflux;

Reference yield:

(R)-3,3-diphenyl-1-methylpyrrolidine[1,2-c]-1,3,2-oxazaborole + (2-chloroethyl)dimethylamine hydrochloride (4584-46-7) + dimethyl sulfide borane (13292-87-0) + (1-methyl-1H-pyrazol-5-yl)(phenyl)methanone (61496-24-0) → (R)-(+)-Cizolirtine (148981-62-8,142155-43-9)

Guidance literature:

With sodium hydroxide; citric acid; sodium chloride; In methanol; toluene;

upstream raw materials:

2-(N,N-dimethylamino)ethanol hydrochloride

(R)-(+)-1-Methyl-α-phenyl-1H-pyrazole-5-methanol

(2-chloroethyl)dimethylamine hydrochloride

dimethyl sulfide borane

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