1-benzyl 3-methyl 2,6-bis(benzyloxy)-4-(2-(methoxy(methyl)amino)-2-oxoethyl)isophthalate

Base Information

Chemical Name:1-benzyl 3-methyl 2,6-bis(benzyloxy)-4-(2-(methoxy(methyl)amino)-2-oxoethyl)isophthalate
CAS No.:1333325-39-5
Molecular Formula:C₃₄H₃₃NO₈
Molecular Weight:583.638
Hs Code.:

Synonyms:1-benzyl 3-methyl 2,6-bis(benzyloxy)-4-(2-(methoxy(methyl)amino)-2-oxoethyl)isophthalate

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Chemical Property of 1-benzyl 3-methyl 2,6-bis(benzyloxy)-4-(2-(methoxy(methyl)amino)-2-oxoethyl)isophthalate

Chemical Property:

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Technology Process of 1-benzyl 3-methyl 2,6-bis(benzyloxy)-4-(2-(methoxy(methyl)amino)-2-oxoethyl)isophthalate

There total 3 articles about 1-benzyl 3-methyl 2,6-bis(benzyloxy)-4-(2-(methoxy(methyl)amino)-2-oxoethyl)isophthalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1333325-53-3
2-(3,5-bis(benzyloxy)-4-(benzyloxycarbonyl)-2-(methoxycarbonyl)phenyl)acetic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1333325-39-5
1-benzyl 3-methyl 2,6-bis(benzyloxy)-4-(2-(methoxy(methyl)amino)-2-oxoethyl)isophthalate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/ol202265g

Reference yield:

: 6121-79-5
dimethyl 4-carboxy-3,5-dihydroxyhomophthalate

: 1333325-39-5
1-benzyl 3-methyl 2,6-bis(benzyloxy)-4-(2-(methoxy(methyl)amino)-2-oxoethyl)isophthalate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 19 h / Reflux

2: lithium hydroxide monohydrate; water / tetrahydrofuran / 24 h / 0 - 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 3 h / 20 °C

With dmap; lithium hydroxide monohydrate; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/ol202265g

Reference yield:

: 100-39-0
benzyl bromide

: 1333325-39-5
1-benzyl 3-methyl 2,6-bis(benzyloxy)-4-(2-(methoxy(methyl)amino)-2-oxoethyl)isophthalate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 19 h / Reflux

2: lithium hydroxide monohydrate; water / tetrahydrofuran / 24 h / 0 - 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 3 h / 20 °C

With dmap; lithium hydroxide monohydrate; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/ol202265g