(1R,3S)-1-((2R,4S)-4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl methanesulfonate

Base Information

Chemical Name:(1R,3S)-1-((2R,4S)-4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl methanesulfonate
CAS No.:1309922-71-1
Molecular Formula:C₂₆H₄₂O₈S
Molecular Weight:514.681
Hs Code.:

Synonyms:(1R,3S)-1-((2R,4S)-4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl methanesulfonate

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Chemical Property of (1R,3S)-1-((2R,4S)-4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl methanesulfonate

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Technology Process of (1R,3S)-1-((2R,4S)-4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl methanesulfonate

There total 14 articles about (1R,3S)-1-((2R,4S)-4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1309922-70-0
(3S,5R)-5-((1R,3S)-1-hydroxy-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyl-dihydrofuran-2(3H)-one

: 124-63-0
methanesulfonyl chloride

: 1309922-71-1
(1R,3S)-1-((2R,4S)-4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1.16667h;
DOI:10.5012/bkcs.2013.34.12.3777

Reference yield:

: 1309922-64-2
(2R,2'R,4R,4'R)-4,4'-diisopropyl-tetrahydro-2,2'-bifuran-5,5'(2H,2'H)-dione

: 1309922-71-1
(1R,3S)-1-((2R,4S)-4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; N²,N²-dimethyl-2-methyl-1,2-propanediamine / tetrahydrofuran; TETRAHYDROPYRANE / 1.33 h / -78 °C

1.2: 1.33 h / -78 °C

1.3: -78 °C / pH 7

2.1: hydrogen / palladium 10% on activated carbon / 4 h / 3102.97 Torr

3.1: triethylamine / dichloromethane / -10 °C

With n-butyllithium; N²,N²-dimethyl-2-methyl-1,2-propanediamine; hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; TETRAHYDROPYRANE; dichloromethane;

Reference yield:

: 1309922-65-3
(3S,5R)-5-((1R,3S)-1-Hydroxy-3-(4-methoxy-3-(methoxypropoxy)benzoyl)-4-methylpentyl)-3-isopropyl-dihydrofuran-2(3H)-one

: 1309922-71-1
(1R,3S)-1-((2R,4S)-4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / 4 h / 3102.97 Torr

2: triethylamine / dichloromethane / -10 °C

With hydrogen; triethylamine; palladium 10% on activated carbon; In dichloromethane;