4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethoxy]-3,5-dimethylbenzaldehyde

Base Information

Chemical Name:4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethoxy]-3,5-dimethylbenzaldehyde
CAS No.:1044872-70-9
Molecular Formula:C₁₉H₁₇NO₄
Molecular Weight:323.348
Hs Code.:

Synonyms:4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethoxy]-3,5-dimethylbenzaldehyde

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Chemical Property of 4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethoxy]-3,5-dimethylbenzaldehyde

Chemical Property:

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Technology Process of 4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethoxy]-3,5-dimethylbenzaldehyde

There total 1 articles about 4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethoxy]-3,5-dimethylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 574-98-1
2-(2-bromoethyl)isoindoline-1,3-dione

: 2233-18-3
4-hydroxy-3,5-dimethylbenzaldehyde

: 1044872-70-9
4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethoxy]-3,5-dimethylbenzaldehyde

Guidance literature:: 4-hydroxy-3,5-dimethylbenzaldehyde; With sodium hydride; In N,N-dimethyl-formamide; for 0.333333h;

2-(2-bromoethyl)isoindoline-1,3-dione; In N,N-dimethyl-formamide; at 65 ℃; for 5h;

With acetic acid; In water;

Reference yield:

: 1044872-70-9
4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethoxy]-3,5-dimethylbenzaldehyde

: 63920-73-0
2-amino-4,6-dimethoxybenzamide

: 1044871-46-6
2-(4-(2-aminoethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

: 1044871-45-5
1-N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-2-N-methylphthalic acid diamide

Guidance literature:: 4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethoxy]-3,5-dimethylbenzaldehyde; 2-amino-4,6-dimethoxybenzamide; With toluene-4-sulfonic acid; sodium hydrogensulfite; In N,N-dimethyl acetamide; for 1.5h; Reflux;

In tetrahydrofuran; at 20 ℃; for 17h;

Reference yield:

: 1044872-70-9
4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethoxy]-3,5-dimethylbenzaldehyde

: 1044871-48-8
N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-4-methoxybenzene-1-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 1.5 h / Reflux

1.2: 17 h / 20 °C

2.1: triethylamine / dichloromethane / 3 h / 20 °C

With toluene-4-sulfonic acid; sodium hydrogensulfite; triethylamine; In dichloromethane; N,N-dimethyl acetamide;