1-N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-2-N-methylphthalic acid diamide

Base Information

Chemical Name:1-N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-2-N-methylphthalic acid diamide
CAS No.:1044871-45-5
Molecular Formula:C₂₉H₃₀N₄O₆
Molecular Weight:530.58
Hs Code.:

Synonyms:1-N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-2-N-methylphthalic acid diamide

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Chemical Property of 1-N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-2-N-methylphthalic acid diamide

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Technology Process of 1-N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-2-N-methylphthalic acid diamide

There total 15 articles about 1-N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-2-N-methylphthalic acid diamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1044871-91-1
2-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl)isoindoline-1,3-dione

: 1044871-46-6
2-(4-(2-aminoethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

: 1044871-45-5
1-N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-2-N-methylphthalic acid diamide

Guidance literature:: With methylamine; In tetrahydrofuran; at 20 ℃; for 17h;

Reference yield: 22.0%

: 1044871-91-1
2-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl)isoindoline-1,3-dione

: 74-89-5
methylamine

: 1044871-46-6
2-(4-(2-aminoethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

: 1044871-45-5
1-N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-2-N-methylphthalic acid diamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 17h;

Reference yield:

: 21577-57-1
2-amino-4,6-dimethoxybenzoic acid

: 1044871-46-6
2-(4-(2-aminoethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

: 1044871-45-5
1-N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-2-N-methylphthalic acid diamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / tetrahydrofuran / 3 h / 20 °C

1.2: 16 h / 20 °C

2.1: toluene-4-sulfonic acid; sodium hydrogensulfite / ISOPROPYLAMIDE / 1.5 h / Heating / reflux

3.1: tetrahydrofuran / 17 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; toluene-4-sulfonic acid; sodium hydrogensulfite; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; ISOPROPYLAMIDE;