(E)-3-(4-benzyloxy-3,5-difluorophenyl)-2-methylacrylic acid ethyl ester

Base Information

Chemical Name:(E)-3-(4-benzyloxy-3,5-difluorophenyl)-2-methylacrylic acid ethyl ester
CAS No.:1224103-92-7
Molecular Formula:C₁₉H₁₈F₂O₃
Molecular Weight:332.347
Hs Code.:

Synonyms:(E)-3-(4-benzyloxy-3,5-difluorophenyl)-2-methylacrylic acid ethyl ester

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Chemical Property of (E)-3-(4-benzyloxy-3,5-difluorophenyl)-2-methylacrylic acid ethyl ester

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Technology Process of (E)-3-(4-benzyloxy-3,5-difluorophenyl)-2-methylacrylic acid ethyl ester

There total 7 articles about (E)-3-(4-benzyloxy-3,5-difluorophenyl)-2-methylacrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1224103-92-7
(E)-3-(4-benzyloxy-3,5-difluorophenyl)-2-methylacrylic acid ethyl ester

Guidance literature:: In tetrahydrofuran; at -78 - 20 ℃; for 12h;

Reference yield:

: 99045-18-8
1-Bromo-3,5-difluoro-4-(benzyloxy)benzene

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 21382-82-1
(carbethoxyethylidene)triphenylphosphorane

: 1224103-92-7
(E)-3-(4-benzyloxy-3,5-difluorophenyl)-2-methylacrylic acid ethyl ester

: ethyl (2E)-3-[3-(benzyloxy)-2,4-difluorophenyl]-2-methylprop-2-enoate

Guidance literature:: 1-Bromo-3,5-difluoro-4-(benzyloxy)benzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

(carbethoxyethylidene)triphenylphosphorane; In toluene; at 110 ℃; for 12h;

Reference yield:

: 99045-18-8
1-Bromo-3,5-difluoro-4-(benzyloxy)benzene

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1224103-92-7
(E)-3-(4-benzyloxy-3,5-difluorophenyl)-2-methylacrylic acid ethyl ester

: ethyl (2E)-3-[3-(benzyloxy)-2,4-difluorophenyl]-2-methylprop-2-enoate

Guidance literature:: 1-Bromo-3,5-difluoro-4-(benzyloxy)benzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 1h;

In toluene; at 110 ℃; for 12h;