{(1R,2R)-2-benzyloxy-1-[(methoxymethylcarbamoyl)methoxylmethyl]propyl}carbamic acid t-butyl ester

Base Information

Chemical Name:{(1R,2R)-2-benzyloxy-1-[(methoxymethylcarbamoyl)methoxylmethyl]propyl}carbamic acid t-butyl ester
CAS No.:1004791-13-2
Molecular Formula:C₂₀H₃₂N₂O₆
Molecular Weight:396.484
Hs Code.:

Synonyms:{(1R,2R)-2-benzyloxy-1-[(methoxymethylcarbamoyl)methoxylmethyl]propyl}carbamic acid t-butyl ester

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Chemical Property of {(1R,2R)-2-benzyloxy-1-[(methoxymethylcarbamoyl)methoxylmethyl]propyl}carbamic acid t-butyl ester

Chemical Property:

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Technology Process of {(1R,2R)-2-benzyloxy-1-[(methoxymethylcarbamoyl)methoxylmethyl]propyl}carbamic acid t-butyl ester

There total 5 articles about {(1R,2R)-2-benzyloxy-1-[(methoxymethylcarbamoyl)methoxylmethyl]propyl}carbamic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1004791-12-1
((2R,3R)-3-benzyloxy-2-t-butoxycarbonyl-aminobutoxy)acetic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1004791-13-2
{(1R,2R)-2-benzyloxy-1-[(methoxymethylcarbamoyl)methoxylmethyl]propyl}carbamic acid t-butyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1004791-09-6
(R)-5-((R)-1-benzyloxyethyl)morpholine-3-one

: 1004791-13-2
{(1R,2R)-2-benzyloxy-1-[(methoxymethylcarbamoyl)methoxylmethyl]propyl}carbamic acid t-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dmap / acetonitrile / 4 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: sodium hydroxide; water / methanol / 3 h / 20 °C

2.2: pH 4

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With sodium hydroxide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; dmap; In methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1004791-10-9
((2R,3R)-3-benzyloxy-2-t-butoxycarbonylaminobutoxy)acetic acid t-butyl ester

: 1004791-13-2
{(1R,2R)-2-benzyloxy-1-[(methoxymethylcarbamoyl)methoxylmethyl]propyl}carbamic acid t-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

1.2: 1 h / 20 °C

1.3: 0 °C

2.1: triethylamine / dmap / acetonitrile / 4 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: sodium hydroxide; water / methanol / 3 h / 20 °C

3.2: pH 4

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With sodium hydroxide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dmap; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;