1-methoxy-4-{1-[(2-methoxypropan-2-yl)oxy]prop-2-yn-1-yl}benzene

Base Information

• Chemical Name: 1-methoxy-4-{1-[(2-methoxypropan-2-yl)oxy]prop-2-yn-1-yl}benzene
• CAS No.: 1448636-75-6
• Molecular Formula: C₁₄H₁₈O₃
• Molecular Weight: 234.295
• Mol file: 1448636-75-6.mol

Synonyms:1-methoxy-4-{1-[(2-methoxypropan-2-yl)oxy]prop-2-yn-1-yl}benzene

Chemical Property of 1-methoxy-4-{1-[(2-methoxypropan-2-yl)oxy]prop-2-yn-1-yl}benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methoxy-4-{1-[(2-methoxypropan-2-yl)oxy]prop-2-yn-1-yl}benzene

There total 2 articles about 1-methoxy-4-{1-[(2-methoxypropan-2-yl)oxy]prop-2-yn-1-yl}benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-Methoxypropene (116-11-0) + 1-(4-methoxyphenyl)-2-propyn-1-ol (19115-30-1) → 1-methoxy-4-{1-[(2-methoxypropan-2-yl)oxy]prop-2-yn-1-yl}benzene (1448636-75-6)

Guidance literature:

With pyridinium p-toluenesulfonate; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1002/ejoc.201301674 DOI:10.1002/ejoc.201301674

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 1-methoxy-4-{1-[(2-methoxypropan-2-yl)oxy]prop-2-yn-1-yl}benzene (1448636-75-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 1 h / -20 - 20 °C / Inert atmosphere

2: pyridinium p-toluenesulfonate / 1.5 h / 0 - 20 °C / Inert atmosphere

With pyridinium p-toluenesulfonate; In tetrahydrofuran;

DOI:10.1002/ejoc.201301674 DOI:10.1002/ejoc.201301674

Reference yield: 94.0%

1-methoxy-4-{1-[(2-methoxypropan-2-yl)oxy]prop-2-yn-1-yl}benzene (1448636-75-6) + p-methoxy-phenylazide (2101-87-3) → trans-3,6-dimethoxy-1,4,5-tris(4-methoxyphenyl)-4,5-dihydro-1H-azepine

Guidance literature:

With Echavarren's catalyst; In dichloromethane; at 20 ℃; for 0.0833333h; diastereoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201600319

upstream raw materials:

2-Methoxypropene

1-(4-methoxyphenyl)-2-propyn-1-ol

4-methoxy-benzaldehyde

Downstream raw materials:

4,8-dimethoxy-2-(4-methoxyphenyl)-1-(4-nitrophenyl)-2,3-dihydro-1H-benz[c]azepine

2-methoxy-3-(4-methoxyphenyl)acrylaldehyde