N-phenylpropionohydrazonoyl chloride

Base Information

• Chemical Name: N-phenylpropionohydrazonoyl chloride
• CAS No.: 115419-52-8
• Molecular Formula: C₉H₁₁ClN₂
• Molecular Weight: 182.653
• Mol file: 115419-52-8.mol

Synonyms:N-phenylpropionohydrazonoyl chloride

Chemical Property of N-phenylpropionohydrazonoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-phenylpropionohydrazonoyl chloride

There total 2 articles about N-phenylpropionohydrazonoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

propionic acid 2-phenylhydrazide (20730-02-3) → N-phenylpropionohydrazonoyl chloride (115419-52-8)

Guidance literature:

With tetrachloromethane; triphenylphosphine; In acetonitrile; for 12h; Ambient temperature;

Reference yield:

phenylhydrazine (100-63-0) → N-phenylpropionohydrazonoyl chloride (115419-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / toluene / Reflux

1.2: 0 - 20 °C

2.1: triphenylphosphine / acetonitrile; tetrachloromethane

With thionyl chloride; triphenylphosphine; In tetrachloromethane; toluene; acetonitrile;

DOI:10.1021/acs.joc.8b00155

Reference yield: 90.0%

1-methyl-1H-imidazole (616-47-7) + N-phenylpropionohydrazonoyl chloride (115419-52-8) → 3-ethyl-1-phenyl-1H-1,2,4-triazole

Guidance literature:

In acetonitrile; at 70 ℃; for 4h;

DOI:10.1039/d0cc01065k

upstream raw materials:

propionic acid 2-phenylhydrazide

phenylhydrazine

Downstream raw materials:

1-formyl-1-phenyl-2-propionylhydrazine

5-ethyl-3-phenyl-1,3,4-oxadiazol-2(3H)-one

3-ethyl-1-phenyl-1H-pyrazole

Refernces

• 1、 Voronin, Vladimir V.,Ledovskaya, Maria S.,Gordeev, Evgeniy G.,Rodygin, Konstantin S.,Ananikov, Valentine P.. "[3+2]-cycloaddition of in situ generated nitrile imines and acetylene for assembling of 1,3-disubstituted pyrazoles with quantitative deuterium labeling". . p. 3819 - 3828. Retrieved 2018/04/14.