3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)benzonitrile

Base Information

Chemical Name:3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)benzonitrile
CAS No.:1352610-23-1
Molecular Formula:C₂₃H₁₇N₇
Molecular Weight:391.435
Hs Code.:

Synonyms:3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)benzonitrile

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Chemical Property of 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)benzonitrile

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Technology Process of 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)benzonitrile

There total 4 articles about 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 356560-84-4
1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione

: 109346-98-7
3-cyanophenyl-1-acetaldehyde

: 1352610-23-1
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)benzonitrile

Guidance literature:: 1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione; 3-cyanophenyl-1-acetaldehyde; With ammonium acetate; In methanol; tert-butyl methyl ether; at 20 ℃; for 1.5h; Inert atmosphere;

With sodium hydrogencarbonate; In methanol; tert-butyl methyl ether; water; pH=8; Inert atmosphere;

Reference yield:

: 614750-82-2
1-(6-methylpyridin-2-yl)-2-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-ethanone

: 1352610-23-1
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethyl sulfoxide; hydrogen bromide / 2 h / 60 - 70 °C

2.1: ammonium acetate / tert-butyl methyl ether; methanol / 1.5 h / 20 °C / Inert atmosphere

2.2: pH 8 / Inert atmosphere

With ammonium acetate; hydrogen bromide; dimethyl sulfoxide; In methanol; tert-butyl methyl ether;

Reference yield:

: 614750-85-5
diphenyl (6-methylpyridin-2-yl)(phenylamino)methylphosphonate

: 1352610-23-1
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / isopropyl alcohol; tetrahydrofuran / 20 °C

1.2: 1 h

1.3: pH 7 - 8

2.1: dimethyl sulfoxide; hydrogen bromide / 2 h / 60 - 70 °C

3.1: ammonium acetate / tert-butyl methyl ether; methanol / 1.5 h / 20 °C / Inert atmosphere

3.2: pH 8 / Inert atmosphere

With ammonium acetate; hydrogen bromide; caesium carbonate; dimethyl sulfoxide; In tetrahydrofuran; methanol; tert-butyl methyl ether; isopropyl alcohol;