1-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[8-(tert-butyl-dimethyl-silanyloxy)-quinolin-6-yl]-propan-2-ol

Base Information

• Chemical Name: 1-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[8-(tert-butyl-dimethyl-silanyloxy)-quinolin-6-yl]-propan-2-ol
• CAS No.: 834906-32-0
• Molecular Formula: C₃₉H₄₅NO₅Si
• Molecular Weight: 635.875
• Mol file: 834906-32-0.mol

Synonyms:1-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[8-(tert-butyl-dimethyl-silanyloxy)-quinolin-6-yl]-propan-2-ol

Chemical Property of 1-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[8-(tert-butyl-dimethyl-silanyloxy)-quinolin-6-yl]-propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[8-(tert-butyl-dimethyl-silanyloxy)-quinolin-6-yl]-propan-2-ol

There total 4 articles about 1-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[8-(tert-butyl-dimethyl-silanyloxy)-quinolin-6-yl]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(S)-glycidyl 4,4’-dimethoxytrityl ether (834906-31-9) + 6-bromo-8-(tert-butyl-dimethyl-silanyloxy)-quinoline (834906-20-6) → 1-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[8-(tert-butyl-dimethyl-silanyloxy)-quinolin-6-yl]-propan-2-ol (834906-32-0)

Guidance literature:

Multistep reaction;

DOI:10.1021/ja043904j

Reference yield:

6-bromo-8-quinolinol (139399-64-7) → 1-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[8-(tert-butyl-dimethyl-silanyloxy)-quinolin-6-yl]-propan-2-ol (834906-32-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; In N,N-dimethyl-formamide;

DOI:10.1021/ja043904j

Reference yield:

6-bromo-8-methoxy-quinoline (103028-32-6) → 1-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[8-(tert-butyl-dimethyl-silanyloxy)-quinolin-6-yl]-propan-2-ol (834906-32-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / aq. HBr / 36 h / Heating

2: 55 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; hydrogen bromide; In N,N-dimethyl-formamide;

DOI:10.1021/ja043904j

upstream raw materials:

(S)-glycidyl 4,4’-dimethoxytrityl ether

6-bromo-8-(tert-butyl-dimethyl-silanyloxy)-quinoline

6-bromo-8-quinolinol

6-bromo-8-methoxy-quinoline

Downstream raw materials:

6-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-8-(tert-butyl-dimethyl-silanyloxy)-quinoline

2,2-Dimethyl-propionic acid 6-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-quinolin-8-yl ester

6-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-quinolin-8-ol

2,2-dimethyl-propionic acid 6-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-quinolin-8-yl ester