(4S)-2-ethoxy-3,4r-dimethyl-5c-phenyl-[1,3,2]oxazaphospholidine 2c-sulfide

Base Information

• Chemical Name: (4S)-2-ethoxy-3,4r-dimethyl-5c-phenyl-[1,3,2]oxazaphospholidine 2c-sulfide
• CAS No.: 57573-34-9
• Molecular Formula: C₁₂H₁₈NO₂PS
• Molecular Weight: 271.32

Synonyms:(4S)-2-ethoxy-3,4r-dimethyl-5c-phenyl-[1,3,2]oxazaphospholidine 2c-sulfide

Chemical Property of (4S)-2-ethoxy-3,4r-dimethyl-5c-phenyl-[1,3,2]oxazaphospholidine 2c-sulfide

Chemical Property:

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Technology Process of (4S)-2-ethoxy-3,4r-dimethyl-5c-phenyl-[1,3,2]oxazaphospholidine 2c-sulfide

There total 3 articles about (4S)-2-ethoxy-3,4r-dimethyl-5c-phenyl-[1,3,2]oxazaphospholidine 2c-sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-ethyl dichlorothiophosphate (1498-64-2) + ephedrine (299-42-3,7009-81-6,90-83-5,6912-63-6) → (2S,4S,5R)-2-ethoxy-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione (1089310-25-7) + (4S)-2-ethoxy-3,4r-dimethyl-5c-phenyl-[1,3,2]oxazaphospholidine 2c-sulfide (57573-34-9)

Guidance literature:

With triethylamine; In dichloromethane; at 5 ℃; for 18h;

Reference yield:

(2R,4S,5R)-(-)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione (57573-32-7) + sodium ethanolate (141-52-6) → (4S)-2-ethoxy-3,4r-dimethyl-5c-phenyl-[1,3,2]oxazaphospholidine 2c-sulfide (57573-34-9)

Guidance literature:

In ethanol;

Reference yield:

→ (4S)-2-ethoxy-3,4r-dimethyl-5c-phenyl-[1,3,2]oxazaphospholidine 2c-sulfide (57573-34-9)

Guidance literature:

Verb. 7, NaOC2H5;

DOI:10.1039/c39750000721

upstream raw materials:

(2R,4S,5R)-(-)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione

sodium ethanolate

O-ethyl dichlorothiophosphate

ephedrine

Downstream raw materials:

(S)-Thiophosphoric acid O-ethyl ester O'-((1R,2S)-2-methylamino-1-phenyl-propyl) ester

(2S,4S,5R)-2-ethoxy-3,4-dimethyl-5-phenyl-1,3,2-thiazaphospholidin-2-one

(2S,4S,5S)-2-ethoxy-3,4-dimethyl-5-phenyl-1,3,2-thiazaphospholidin-2-one

(2R,4S,5S)-2-ethoxy-3,4-dimethyl-5-phenyl-1,3,2-thiazaphospholidin-2-one

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