N-cyclohexyl-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

Base Information

Chemical Name:N-cyclohexyl-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS No.:1314801-55-2
Molecular Formula:C₁₈H₂₃N₃O₂
Molecular Weight:313.4
Hs Code.:

Synonyms:N-cyclohexyl-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-cyclohexyl-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

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Technology Process of N-cyclohexyl-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

There total 3 articles about N-cyclohexyl-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 108-91-8,157973-60-9
cyclohexylamine

: 60750-37-0
1,2,3,4-tetrahydro-6-methyl-2-oxo-4-phenylpyrimidine-5-carboxylic acid

: 1314801-55-2
N-cyclohexyl-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

Guidance literature:: With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 45 ℃; for 24.5h; Inert atmosphere;

Reference yield: 47.0%

: 1132-42-9
N-cyclohexylacetoacetamide

: 100-52-7
benzaldehyde

: 57-13-6
urea

: 1314801-55-2
N-cyclohexyl-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

Guidance literature:: With zirconium(IV) chloride; In acetonitrile; for 10h; Reflux;
DOI:10.1515/znb-2010-0408

Reference yield:

: 108-91-8,157973-60-9
cyclohexylamine

: 1314801-55-2
N-cyclohexyl-4-phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: toluene

2: ethanol / Acidic conditions; Reflux

In ethanol; toluene; 2: |Biginelli Pyrimidone Synthesis;
DOI:10.1111/cbdd.12373