(S)-isopropyl pivaloyloxymethyl 1-(tert-butyldimethylsilyl)-2-(tert-butyldimethylsilyloxymethyl)-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

Base Information

Chemical Name:(S)-isopropyl pivaloyloxymethyl 1-(tert-butyldimethylsilyl)-2-(tert-butyldimethylsilyloxymethyl)-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
CAS No.:174840-10-9
Molecular Formula:C₃₆H₅₇Cl₂NO₇Si₂
Molecular Weight:742.928
Hs Code.:

(S)-isopropyl pivaloyloxymethyl 1-(tert-butyldimethylsilyl)-2-(tert-butyldimethylsilyloxymethyl)-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

Synonyms:(S)-isopropyl pivaloyloxymethyl 1-(tert-butyldimethylsilyl)-2-(tert-butyldimethylsilyloxymethyl)-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

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Chemical Property of (S)-isopropyl pivaloyloxymethyl 1-(tert-butyldimethylsilyl)-2-(tert-butyldimethylsilyloxymethyl)-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

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Technology Process of (S)-isopropyl pivaloyloxymethyl 1-(tert-butyldimethylsilyl)-2-(tert-butyldimethylsilyloxymethyl)-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

There total 6 articles about (S)-isopropyl pivaloyloxymethyl 1-(tert-butyldimethylsilyl)-2-(tert-butyldimethylsilyloxymethyl)-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 174840-09-6
(S)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-6-methyl-3,5-pyridinedicarboxylate

: 174840-10-9
(S)-isopropyl pivaloyloxymethyl 1-(tert-butyldimethylsilyl)-2-(tert-butyldimethylsilyloxymethyl)-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;

Reference yield:

: 174840-08-5
(S)-isopropyl pivaloyloxymethyl 2-bromomethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

: 174840-10-9
(S)-isopropyl pivaloyloxymethyl 1-(tert-butyldimethylsilyl)-2-(tert-butyldimethylsilyloxymethyl)-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: aq. AgNO₃ / acetone / 18 h / Ambient temperature

2: imidazole / dimethylformamide / 5 h / Ambient temperature

With 1H-imidazole; silver nitrate; In N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.45.869

Reference yield:

: 164263-08-5
(R)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid

: 174840-10-9
(S)-isopropyl pivaloyloxymethyl 1-(tert-butyldimethylsilyl)-2-(tert-butyldimethylsilyloxymethyl)-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexylcarbodiimide, 4-dimethylaminopyridine / tetrahydrofuran / 18 h

2: pyridinium bromoperbromide / CH₂Cl₂ / 1 h / -20 °C

3: aq. AgNO₃ / acetone / 18 h / Ambient temperature

4: imidazole / dimethylformamide / 5 h / Ambient temperature

With 1H-imidazole; dmap; pyridinium perbromide hydrobromide; silver nitrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.45.869