(S)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-6-methyl-3,5-pyridinedicarboxylate

Base Information

Chemical Name:(S)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-6-methyl-3,5-pyridinedicarboxylate
CAS No.:174840-09-6
Molecular Formula:C₂₄H₂₉Cl₂NO₇
Molecular Weight:514.403
Hs Code.:

Synonyms:(S)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-6-methyl-3,5-pyridinedicarboxylate

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Chemical Property of (S)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-6-methyl-3,5-pyridinedicarboxylate

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Technology Process of (S)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-6-methyl-3,5-pyridinedicarboxylate

There total 5 articles about (S)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-6-methyl-3,5-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 174840-08-5
(S)-isopropyl pivaloyloxymethyl 2-bromomethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

: 174840-09-6
(S)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-6-methyl-3,5-pyridinedicarboxylate

Guidance literature:: With silver nitrate; acetone;

Reference yield:

: 164263-08-5
(R)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid

: 174840-09-6
(S)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-6-methyl-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexylcarbodiimide, 4-dimethylaminopyridine / tetrahydrofuran / 18 h

2: pyridinium bromoperbromide / CH₂Cl₂ / 1 h / -20 °C

3: aq. AgNO₃ / acetone / 18 h / Ambient temperature

With dmap; pyridinium perbromide hydrobromide; silver nitrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1248/cpb.45.869

Reference yield:

: 174840-07-4
(R)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

: 174840-09-6
(S)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-6-methyl-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium bromoperbromide / CH₂Cl₂ / 1 h / -20 °C

2: aq. AgNO₃ / acetone / 18 h / Ambient temperature

With pyridinium perbromide hydrobromide; silver nitrate; In dichloromethane; acetone;
DOI:10.1248/cpb.45.869