α-ethyl-4-(1H-imidazol-1-yl)-α-methyl-β-oxobenzenepropanoic acid methyl ester

Base Information

Chemical Name:α-ethyl-4-(1H-imidazol-1-yl)-α-methyl-β-oxobenzenepropanoic acid methyl ester
CAS No.:108818-65-1
Molecular Formula:C₁₆H₁₈N₂O₃
Molecular Weight:286.331
Hs Code.:

Synonyms:α-ethyl-4-(1H-imidazol-1-yl)-α-methyl-β-oxobenzenepropanoic acid methyl ester

Suppliers and Price of α-ethyl-4-(1H-imidazol-1-yl)-α-methyl-β-oxobenzenepropanoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α-ethyl-4-(1H-imidazol-1-yl)-α-methyl-β-oxobenzenepropanoic acid methyl ester

Chemical Property:

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Technology Process of α-ethyl-4-(1H-imidazol-1-yl)-α-methyl-β-oxobenzenepropanoic acid methyl ester

There total 3 articles about α-ethyl-4-(1H-imidazol-1-yl)-α-methyl-β-oxobenzenepropanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-03-6
ethyl iodide

: 84243-56-1
4-(1H-imidazol-1-yl)-β-oxobenzenepropanoic acid methyl ester

: 74-88-4
methyl iodide

: 108818-65-1
α-ethyl-4-(1H-imidazol-1-yl)-α-methyl-β-oxobenzenepropanoic acid methyl ester

Guidance literature:: In N-methyl-acetamide;

Reference yield:

: 108818-61-7
3-(4-Imidazol-1-yl-phenyl)-2-methyl-3-oxo-propionic acid methyl ester

: 108818-65-1
α-ethyl-4-(1H-imidazol-1-yl)-α-methyl-β-oxobenzenepropanoic acid methyl ester

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMF, from 10 to 15 deg C, 2.) DMF, RT, 20 h;
DOI:10.1021/jm00393a007

Reference yield:

: 84243-56-1
4-(1H-imidazol-1-yl)-β-oxobenzenepropanoic acid methyl ester

: 108818-65-1
α-ethyl-4-(1H-imidazol-1-yl)-α-methyl-β-oxobenzenepropanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, from 10 to 15 deg C, 2.) DMF, RT, 20 h

2: 1.) NaH / 1.) DMF, from 10 to 15 deg C, 2.) DMF, RT, 20 h

With sodium hydride;
DOI:10.1021/jm00393a007