N,N-DIMETHYLBENZENESULPHONAMIDE

Base Information

• Chemical Name: N,N-DIMETHYLBENZENESULPHONAMIDE
• CAS No.: 14417-01-7
• Molecular Formula: C8H11 N O2 S
• Molecular Weight: 185.247
• Hs Code.: 2935009090
• Mol file: 14417-01-7.mol

Synonyms:Benzenesulfonicdimethylamide; N,N-Dimethylbenzenesulfonamide; NSC 86567

Chemical Property of N,N-DIMETHYLBENZENESULPHONAMIDE

Chemical Property:

• Vapor Pressure: 0.00308mmHg at 25°C
• Melting Point: 45.5-46.5 °C
• Boiling Point: 283.9°Cat760mmHg
• PKA: -4.73±0.70(Predicted)
• Flash Point: 125.5°C
• PSA: 45.76000
• Density: 1.195g/cm³
• LogP: 2.01770

Purity/Quality:

98%min ^*data from raw suppliers

N,N-Dimethylbenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N,N-Dimethylbenzenesulfonamide is an intermediate used in the preparation of phenylsulfonamides with anticonvulsant properties for epilepsy treatment.

Technology Process of N,N-DIMETHYLBENZENESULPHONAMIDE

There total 42 articles about N,N-DIMETHYLBENZENESULPHONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl(phenylsulfonyl)amide (5183-78-8) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → N,N-dimethylbenzenesulfonamide (14417-01-7)

Guidance literature:

at 90 ℃; for 10h;

Reference yield: 97.0%

dimethyl amine (124-40-3) + benzenesulfonyl chloride (98-09-9) → N,N-dimethylbenzenesulfonamide (14417-01-7)

Guidance literature:

In tetrahydrofuran; water; at 0 - 50 ℃; for 1h;

Reference yield: 92.0%

N,N-Dimethylcarbamidsaeure-trimethylsilylester (32115-55-2) + benzenesulfonyl chloride (98-09-9) → N,N-dimethylbenzenesulfonamide (14417-01-7)

Guidance literature:

In dichloromethane; at 80 ℃; for 2h;

DOI:10.1016/S0022-328X(00)99291-X

upstream raw materials:

dimethyl amine

benzenesulfonyl chloride

diethyl ether

dimethylammonium dimethyldithiocarbamate

Downstream raw materials:

benzenesulfonic acid

dimethyl amine

benzenesulfonyl chloride

(2-(N,N-dimethylsulfamoyl)phenyl)boronic acid

Refernces

• 1、 Haakkinen, A.-M.,Ruostesuo, P.. "Carbon-13, Nitrogen-15, Oxygen-17 and Sulphur-33 NMR Chemical Shifts of Some Sulphur Amides and Related Compounds". . p. 424 - 427. Retrieved 1985.
• 2、 Surry, David S.,Fox, David J.,Macdonald, Simon J. F.,Spring, David R.. "Aryl-aryl coupling via directed lithiation and oxidation". . p. 2589 - 2590. Retrieved 2005.
• 3、 Fu, Ying,Wu, Qing-Kui,Du, Zhengyin. "Debenzylative Sulfonylation of Tertiary Benzylamines Promoted by Visible Light". supporting information. p. 1896 - 1900. Retrieved 2021/04/06.
• 4、 Chen, Gen-Qiang,Xia, Yan-Fei,Yang, Jin-Ming,Che, Zhi-Ping,Sun, Di,Li, Shen,Tian, Yue-E,Liu, Sheng-Ming,Jiang, Jia,Lin, Xiao-Min. "Controlled synthesis of N, N-dimethylarylsulfonamide derivatives as nematicidal agents". . p. 1197 - 1206. Retrieved 2019/12/03.