3-[3-cyclohexylamino-4-(diphenylphosphinoyl)-4,5,6,7-tetrahydro-2H-indazol-2-yl]propionitrile

Base Information

Chemical Name:3-[3-cyclohexylamino-4-(diphenylphosphinoyl)-4,5,6,7-tetrahydro-2H-indazol-2-yl]propionitrile
CAS No.:1347761-78-7
Molecular Formula:C₂₈H₃₃N₄OP
Molecular Weight:472.57
Hs Code.:

Synonyms:3-[3-cyclohexylamino-4-(diphenylphosphinoyl)-4,5,6,7-tetrahydro-2H-indazol-2-yl]propionitrile

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Chemical Property of 3-[3-cyclohexylamino-4-(diphenylphosphinoyl)-4,5,6,7-tetrahydro-2H-indazol-2-yl]propionitrile

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Technology Process of 3-[3-cyclohexylamino-4-(diphenylphosphinoyl)-4,5,6,7-tetrahydro-2H-indazol-2-yl]propionitrile

There total 4 articles about 3-[3-cyclohexylamino-4-(diphenylphosphinoyl)-4,5,6,7-tetrahydro-2H-indazol-2-yl]propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1347761-58-3
2-(diphenylphosphinoyl)-6-oxocyclohexylcarbothioic acid cyclohexylamide

: 353-07-1
3-hydrazinylpropanenitrile

: 1347761-78-7
3-[3-cyclohexylamino-4-(diphenylphosphinoyl)-4,5,6,7-tetrahydro-2H-indazol-2-yl]propionitrile

Guidance literature:: In chloroform; at 20 ℃; for 24h;
DOI:10.1016/j.tet.2011.09.093

Reference yield:

: 930-68-7
cyclohexenone

: 1347761-78-7
3-[3-cyclohexylamino-4-(diphenylphosphinoyl)-4,5,6,7-tetrahydro-2H-indazol-2-yl]propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 20 °C / Inert atmosphere

1.2: 2 h / Inert atmosphere; Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

2.3: Inert atmosphere; Saturated solution

3.1: chloroform / 24 h / 20 °C

With potassium tert-butylate; acetic acid; In tetrahydrofuran; chloroform; 1.1: Michael addition;
DOI:10.1016/j.tet.2011.09.093

Reference yield:

: 89358-47-4
3-(diphenylphosphoryl)cyclohexan-1-one

: 1347761-78-7
3-[3-cyclohexylamino-4-(diphenylphosphinoyl)-4,5,6,7-tetrahydro-2H-indazol-2-yl]propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

1.3: Inert atmosphere; Saturated solution

2.1: chloroform / 24 h / 20 °C

With potassium tert-butylate; In tetrahydrofuran; chloroform;
DOI:10.1016/j.tet.2011.09.093