1-(1-benzyl-1H-indol-3-yl)-N,N-dimethylmethanamine

Base Information

• Chemical Name: 1-(1-benzyl-1H-indol-3-yl)-N,N-dimethylmethanamine
• CAS No.: 56026-56-3
• Molecular Formula: C₁₈H₂₀N₂
• Molecular Weight: 264.37
• Mol file: 56026-56-3.mol

Synonyms:1-(1-benzyl-1H-indol-3-yl)-N,N-dimethylmethanamine

Chemical Property of 1-(1-benzyl-1H-indol-3-yl)-N,N-dimethylmethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1-benzyl-1H-indol-3-yl)-N,N-dimethylmethanamine

There total 8 articles about 1-(1-benzyl-1H-indol-3-yl)-N,N-dimethylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(Dimethylaminomethyl)indole (87-52-5) + benzyl bromide (100-39-0) → 1-(1-benzyl-1H-indol-3-yl)-N,N-dimethylmethanamine (56026-56-3)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran;

Reference yield: 95.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-benzylindole (3377-71-7) + dimethyl amine (124-40-3) → 1-(1-benzyl-1H-indol-3-yl)-N,N-dimethylmethanamine (56026-56-3)

Guidance literature:

formaldehyd; dimethyl amine; With acetic acid; In water; at 20 ℃; for 0.166667h; Inert atmosphere;

N-benzylindole; With acetic acid; In water; at 0 - 20 ℃; for 24.08h; Inert atmosphere;

DOI:10.1016/j.ejmech.2018.07.030

Reference yield:

1-indoline (496-15-1) → 1-(1-benzyl-1H-indol-3-yl)-N,N-dimethylmethanamine (56026-56-3)

Guidance literature:

Multi-step reaction with 2 steps

1: benzoic acid / toluene / 0.5 h / 200 °C / Sealed tube; Microwave irradiation

2: acetic acid / water / 20 °C / Inert atmosphere

With acetic acid; benzoic acid; In water; toluene; 2: |Mannich Aminomethylation;

DOI:10.1039/c3md00042g

upstream raw materials:

formaldehyd

N-benzylindole

dimethyl amine

3-(Dimethylaminomethyl)indole

Downstream raw materials:

1-benzyl-3-bromo-1H-indole

1-(1-benzyl-1H-indol-3-yl)-N,N,N-trimethylmethanaminium iodide

1-benzyl-3-methyl-1H-indole

1-Benzylindole-3-carboxaldehyde