4-chloro-1-(phenoxycarbonyl)-2-n-propyl-1,2-dihydropyridine

Base Information

• Chemical Name: 4-chloro-1-(phenoxycarbonyl)-2-n-propyl-1,2-dihydropyridine
• CAS No.: 132410-17-4
• Molecular Formula: C₁₅H₁₆ClNO₂
• Molecular Weight: 277.751
• Mol file: 132410-17-4.mol

Synonyms:4-chloro-1-(phenoxycarbonyl)-2-n-propyl-1,2-dihydropyridine

Chemical Property of 4-chloro-1-(phenoxycarbonyl)-2-n-propyl-1,2-dihydropyridine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-chloro-1-(phenoxycarbonyl)-2-n-propyl-1,2-dihydropyridine

There total 2 articles about 4-chloro-1-(phenoxycarbonyl)-2-n-propyl-1,2-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Chloropyridine (626-61-9) + 1-propylmagnesium chloride (2234-82-4) + phenyl chloroformate (1885-14-9) → 4-chloro-1-(phenoxycarbonyl)-2-n-propyl-1,2-dihydropyridine (132410-17-4)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/jo00222a050

Reference yield:

4-Chloropyridine (626-61-9) + 1-propylmagnesium chloride (2234-82-4) → 4-chloro-1-(phenoxycarbonyl)-2-n-propyl-1,2-dihydropyridine (132410-17-4)

Guidance literature:

Yield given. Multistep reaction; 1) THF, Et₂O, -78 deg C, 20 min, 2) -78 deg C, 30 min;

DOI:10.1021/jo00007a044

Reference yield:

4-chloro-1-(phenoxycarbonyl)-2-n-propyl-1,2-dihydropyridine (132410-17-4) → 4-chloro-2-propylpyridine (93856-98-5)

Guidance literature:

With o-tetrachloroquinone; acetic acid; In toluene; for 24h; Yield given; Ambient temperature;

DOI:10.1021/jo00222a050

upstream raw materials:

4-Chloropyridine

1-propylmagnesium chloride

phenyl chloroformate

Downstream raw materials:

4-chloro-2-propylpyridine