n-Hydroxy-n'-methylbenzenecarboximidamide

Base Information

• Chemical Name: n-Hydroxy-n'-methylbenzenecarboximidamide
• CAS No.: 28267-98-3
• Molecular Formula: C8H10 N2 O
• Molecular Weight: 150.18
• NSC Number: 114496
• DSSTox Substance ID: DTXSID40950979
• Nikkaji Number: J1.339.522E
• Mol file: 28267-98-3.mol

Synonyms:28267-98-3;n-hydroxy-n'-methylbenzenecarboximidamide;N-methylbenzamidoxime;NSC114496;SCHEMBL3773521;SCHEMBL12116657;DTXSID40950979;NSC-114496

Chemical Property of n-Hydroxy-n'-methylbenzenecarboximidamide

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 150.079312947
• Heavy Atom Count: 11
• Complexity: 139

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN=C(C1=CC=CC=C1)NO

Technology Process of n-Hydroxy-n'-methylbenzenecarboximidamide

There total 11 articles about n-Hydroxy-n'-methylbenzenecarboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.5%

benzohydroximoyl chloride (698-16-8) + methylamine (74-89-5) → (Z)-N-Methylbenzamid-oxim (28267-98-3)

Guidance literature:

With triethylamine; In diethyl ether; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ic101714q

Reference yield: 76.0%

methylamine (74-89-5) + phenylhydroxamoyl chloride (934-16-7) → (Z)-N-Methylbenzamid-oxim (28267-98-3) + methylamine hydrochloride (593-51-1)

Guidance literature:

In diethyl ether; for 48h; Ambient temperature;

DOI:10.1016/S0040-4020(96)01088-5

Reference yield: 72.0%

3-phenyl-5-trinitromethyl-1,2,4-oxadiazole (110621-89-1) → N'-hydroxy-N-methylbenzimidamide (28267-98-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 25 ℃; for 4h;

DOI:10.1023/B:RUJO.0000034958.53324.bc

upstream raw materials:

4-methyl-3-phenyl-1,2,4-oxadiazol-5(4H)-one

3-(Acetylamino)-4-phenylfurazan

methylamine

3-phenyl-5-trinitromethyl-1,2,4-oxadiazole

Downstream raw materials:

3-methyl-4-phenyl-3H-[1,2,3,5]oxathiadiazole 2-oxide

1,1,3-trimethylurea

Methylbenzamidin

3-phenyl-4-methyl-Δ²-dihydro-1,2,4-oxadiazine-5-one