3,5-diphenyl-1,2,4-oxadiazole

Base Information

• Chemical Name: 3,5-diphenyl-1,2,4-oxadiazole
• CAS No.: 888-71-1
• Molecular Formula: C14H10 N2 O
• Molecular Weight: 222.246
• Hs Code.: 2934999090
• Mol file: 888-71-1.mol

Synonyms:3,5-Diphenyl-1,2,4-oxadiazole;NSC 400077

Chemical Property of 3,5-diphenyl-1,2,4-oxadiazole

Chemical Property:

• Vapor Pressure: 1.32E-05mmHg at 25°C
• Melting Point: 109°C
• Refractive Index: 1.5910 (estimate)
• Boiling Point: 378.9°C at 760 mmHg
• Flash Point: 182.7°C
• PSA: 38.92000
• Density: 1.174g/cm³
• LogP: 3.40360

Purity/Quality:

99% ^*data from raw suppliers

Diphenyl-1,2,4-oxadiazole >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-diphenyl-1,2,4-oxadiazole

There total 201 articles about 3,5-diphenyl-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C17H19N3O (85598-29-4) → 3,5-diphenyl-1,2,4-oxadiazole (888-71-1) + trimethylamine (75-50-3)

Guidance literature:

at 210 ℃; for 0.0833333h;

Reference yield: 95.0%

3,5-diphenyl-1,2,4-oxadiazole-4-oxide (20594-92-7) + cyclohexa-1,3-diene (1165952-91-9) → 3,5-diphenyl-1,2,4-oxadiazole (888-71-1) + N-benzoyl-7-oxa-8-azabicyclo<2.2.2>oct-5-ene (70156-86-4,96093-86-6,146387-03-3) + benzonitrile (100-47-0)

Guidance literature:

In methanol; for 5h; Irradiation;

DOI:10.1016/S0040-4039(98)02416-2

Reference yield: 87.0%

N'-((3-oxo-1,3-diphenylprop-1-en-1-yl)oxy)benzimidamide (1533419-10-1) → 3,5-diphenyl-1,2,4-oxadiazole (888-71-1) + acetophenone (98-86-2)

Guidance literature:

With potassium hydroxide; In 1,4-dioxane; at 100 ℃; for 5h; under 5.17162 Torr; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;

DOI:10.1016/j.tet.2013.12.043

upstream raw materials:

pyridine

nitromethane

benzoyl chloride

1,2-Diphenyl-ethane-1,2-dione dioxime

Downstream raw materials:

phenyl isocyanate

benzonitrile

2-phenyl-4(3H)-quinazolinone

N-benzoyl-N'-methoxy-benzamidine

Refernces

• 1、 Hu, Aixi,Jiang, chan,Li, mingfang,Xu, Leitao,Ye, Jiao,Yi, Yangjie. "Electrochemical synthesis of 1,2,4-oxadiazoles from amidoximes through dehydrogenative cyclization". . p. 10611 - 10616. Retrieved 2021/12/27.
• 2、 Wang, Xuetong,Wang, Yin,Liu, Xiaoling,He, Tingshu,Li, Lingli,Wu, Huili,Zhou, Shangjun,Li, Dan,Liao, Siwei,Xu, Ping,Huang, Xing,Yuan, Jianyong. "Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles". . . Retrieved 2021/10/14.