2-(6-(aminomethyl)pyridin-3-yl)-N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)propanamide

Base Information

Chemical Name:2-(6-(aminomethyl)pyridin-3-yl)-N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)propanamide
CAS No.:1419602-79-1
Molecular Formula:C₂₀H₁₉ClF₃N₅O
Molecular Weight:437.852
Hs Code.:

Synonyms:2-(6-(aminomethyl)pyridin-3-yl)-N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)propanamide

Suppliers and Price of 2-(6-(aminomethyl)pyridin-3-yl)-N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)propanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(6-(aminomethyl)pyridin-3-yl)-N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(6-(aminomethyl)pyridin-3-yl)-N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)propanamide

There total 13 articles about 2-(6-(aminomethyl)pyridin-3-yl)-N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1419602-77-9
tert-butyl (5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)methylcarbamate

: 1419602-79-1
2-(6-(aminomethyl)pyridin-3-yl)-N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)propanamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 23 ℃; Inert atmosphere;

Reference yield:

: 14763-20-3
3-chlorophenyl hydrazine

: 1419602-79-1
2-(6-(aminomethyl)pyridin-3-yl)-N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)propanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethanol / 3 h / Reflux

2.1: potassium iodide; isopentyl nitrite / acetonitrile / 20 h / 0 - 1000 °C

3.1: 1-methyl-pyrrolidin-2-one / 2 h / 200 °C

4.1: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 23 °C

6.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate; methanol / 1 h / 0 °C

6.2: 1 h / 23 °C

7.1: trifluoroacetic acid / dichloromethane / 23 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; potassium iodide; isopentyl nitrite; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 108-42-9
3-chloro-aniline

: 1419602-79-1
2-(6-(aminomethyl)pyridin-3-yl)-N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)propanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / water / 0.17 h / -5 - 0 °C

1.2: 5 h / -5 - 0 °C

2.1: ethanol / 5 h / Reflux

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3.25 h / 23 °C

4.1: triethylamine / toluene / 20 h / 80 °C

5.1: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 23 °C

7.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate; methanol / 1 h / 0 °C

7.2: 1 h / 23 °C

8.1: trifluoroacetic acid / dichloromethane / 23 °C / Inert atmosphere

With hydrogenchloride; methanol; sodium tetrahydroborate; N-chloro-succinimide; nickel(II) chloride hexahydrate; ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;