N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(methylsulfonamidomethyl)pyridin-3-yl)propanamide

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Chemical Name:N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(methylsulfonamidomethyl)pyridin-3-yl)propanamide
CAS No.:1419597-69-5
Molecular Formula:C₂₁H₂₁ClF₃N₅O₃S
Molecular Weight:515.944
Hs Code.:

Synonyms:N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(methylsulfonamidomethyl)pyridin-3-yl)propanamide

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Chemical Property of N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(methylsulfonamidomethyl)pyridin-3-yl)propanamide

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Technology Process of N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(methylsulfonamidomethyl)pyridin-3-yl)propanamide

There total 14 articles about N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(methylsulfonamidomethyl)pyridin-3-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1419602-79-1
2-(6-(aminomethyl)pyridin-3-yl)-N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)propanamide

: 124-63-0
methanesulfonyl chloride

: 1419597-69-5
N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(methylsulfonamidomethyl)pyridin-3-yl)propanamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;

Reference yield:

: 14763-20-3
3-chlorophenyl hydrazine

: 1419597-69-5
N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(methylsulfonamidomethyl)pyridin-3-yl)propanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol / 3 h / Reflux

2.1: potassium iodide; isopentyl nitrite / acetonitrile / 20 h / 0 - 1000 °C

3.1: 1-methyl-pyrrolidin-2-one / 2 h / 200 °C

4.1: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 23 °C

6.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate; methanol / 1 h / 0 °C

6.2: 1 h / 23 °C

7.1: trifluoroacetic acid / dichloromethane / 23 °C / Inert atmosphere

8.1: triethylamine / dichloromethane / 0 °C

With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; potassium iodide; isopentyl nitrite; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 108-42-9
3-chloro-aniline

: 1419597-69-5
N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(methylsulfonamidomethyl)pyridin-3-yl)propanamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride / water / 0.17 h / -5 - 0 °C

1.2: 5 h / -5 - 0 °C

2.1: ethanol / 5 h / Reflux

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3.25 h / 23 °C

4.1: triethylamine / toluene / 20 h / 80 °C

5.1: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 23 °C

7.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate; methanol / 1 h / 0 °C

7.2: 1 h / 23 °C

8.1: trifluoroacetic acid / dichloromethane / 23 °C / Inert atmosphere

9.1: triethylamine / dichloromethane / 0 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; N-chloro-succinimide; nickel(II) chloride hexahydrate; ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;