tert-butyl (5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)methylcarbamate

Base Information

Chemical Name:tert-butyl (5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)methylcarbamate
CAS No.:1419602-77-9
Molecular Formula:C₂₅H₂₇ClF₃N₅O₃
Molecular Weight:537.969
Hs Code.:

Synonyms:tert-butyl (5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)methylcarbamate

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Chemical Property of tert-butyl (5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)methylcarbamate

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Technology Process of tert-butyl (5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)methylcarbamate

There total 11 articles about tert-butyl (5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1419603-08-9
N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(cyanomethyl)pyridin-3-yl)propanamide

: 1419602-77-9
tert-butyl (5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)methylcarbamate

Guidance literature:: di-tert-butyl dicarbonate; N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(cyanomethyl)pyridin-3-yl)propanamide; With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; at 0 ℃; for 1h;

With 3-azapentane-1,5-diamine; In methanol; at 23 ℃; for 1h;

Reference yield:

: 14763-20-3
3-chlorophenyl hydrazine

: 1419602-77-9
tert-butyl (5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 3 h / Reflux

2.1: potassium iodide; isopentyl nitrite / acetonitrile / 20 h / 0 - 1000 °C

3.1: 1-methyl-pyrrolidin-2-one / 2 h / 200 °C

4.1: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 23 °C

6.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate; methanol / 1 h / 0 °C

6.2: 1 h / 23 °C

With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; isopentyl nitrite; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 108-42-9
3-chloro-aniline

: 1419602-77-9
tert-butyl (5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)pyridin-2-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / water / 0.17 h / -5 - 0 °C

1.2: 5 h / -5 - 0 °C

2.1: ethanol / 5 h / Reflux

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3.25 h / 23 °C

4.1: triethylamine / toluene / 20 h / 80 °C

5.1: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 23 °C

7.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate; methanol / 1 h / 0 °C

7.2: 1 h / 23 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; N-chloro-succinimide; nickel(II) chloride hexahydrate; ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; ethanol; water; N,N-dimethyl-formamide; toluene;