(S)-6-Amino-2-{(S)-2-[(S)-2-(2-{2-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-hexanoic acid

Base Information

• Chemical Name: (S)-6-Amino-2-{(S)-2-[(S)-2-(2-{2-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-hexanoic acid
• CAS No.: 98317-58-9
• Molecular Formula: C₃₉H₅₇N₇O₁₀
• Molecular Weight: 783.922
• Mol file: 98317-58-9.mol

Synonyms:

Chemical Property of (S)-6-Amino-2-{(S)-2-[(S)-2-(2-{2-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-hexanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-6-Amino-2-{(S)-2-[(S)-2-(2-{2-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-hexanoic acid

There total 7 articles about (S)-6-Amino-2-{(S)-2-[(S)-2-(2-{2-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-ε-benzyloxycarbonyllysine Benzyl Ester (98317-55-6) → (S)-6-Amino-2-{(S)-2-[(S)-2-(2-{2-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-hexanoic acid (98317-58-9)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; for 3h; Ambient temperature;

DOI:10.1135/cccc19851329

Reference yield:

Lys(Z)-OBzl (24458-14-8) → (S)-6-Amino-2-{(S)-2-[(S)-2-(2-{2-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-hexanoic acid (98317-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / 1-hydroxybenzotriazol, dicyclohexylcarbodiimide / dimethylformamide / 1 h / -20 - 0 °C / O deg C, overnight

2: ammonium formate / 10percent palladium on carbon / methanol / 3 h / Ambient temperature

With ammonium formate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1135/cccc19851329

Reference yield:

N-tert-butyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine (64963-27-5) → (S)-6-Amino-2-{(S)-2-[(S)-2-(2-{2-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-hexanoic acid (98317-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / 1-hydroxybenzotriazol, dicyclohexylcarbodiimide / dimethylformamide / 1 h / -20 - 0 °C / O deg C, overnight

2: ammonium formate / 10percent palladium on carbon / methanol / 3 h / Ambient temperature

With ammonium formate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1135/cccc19851329

upstream raw materials:

Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-ε-benzyloxycarbonyllysine Benzyl Ester

Lys(Z)-OBzl

N-tert-butyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine

Boc-Tyr-OH

Downstream raw materials:

Tyrosyl-glycyl-glycyl-phenylalanyl-leucyl-lysine