3-[(4S,5S)-3-benzyloxycarbonyl-2,2-dimethyl-4-isobutyloxazolidin-5-yl]-2(E)-propenoic acid isobutylamide

Base Information

Chemical Name:3-[(4S,5S)-3-benzyloxycarbonyl-2,2-dimethyl-4-isobutyloxazolidin-5-yl]-2(E)-propenoic acid isobutylamide
CAS No.:118741-37-0
Molecular Formula:C₂₄H₃₆N₂O₄
Molecular Weight:416.561
Hs Code.:

Synonyms:3-[(4S,5S)-3-benzyloxycarbonyl-2,2-dimethyl-4-isobutyloxazolidin-5-yl]-2(E)-propenoic acid isobutylamide

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Chemical Property of 3-[(4S,5S)-3-benzyloxycarbonyl-2,2-dimethyl-4-isobutyloxazolidin-5-yl]-2(E)-propenoic acid isobutylamide

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Technology Process of 3-[(4S,5S)-3-benzyloxycarbonyl-2,2-dimethyl-4-isobutyloxazolidin-5-yl]-2(E)-propenoic acid isobutylamide

There total 4 articles about 3-[(4S,5S)-3-benzyloxycarbonyl-2,2-dimethyl-4-isobutyloxazolidin-5-yl]-2(E)-propenoic acid isobutylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4129-17-3
diphenylphosphoranyl azide

: 78-81-9
isobutylamine

: 79-10-7
acrylic acid

: 118741-37-0
3-[(4S,5S)-3-benzyloxycarbonyl-2,2-dimethyl-4-isobutyloxazolidin-5-yl]-2(E)-propenoic acid isobutylamide

Guidance literature:: With triethylamine; In N-methyl-acetamide; hexane; ethyl acetate;

Reference yield:

: 116993-95-4
(4S,5S)-3-Benzyloxycarbonyl-5-formyl-4-isobutyl-2,2-dimethyloxazolidine

: 118741-37-0
(4S,5S)-4-Isobutyl-5-((E)-2-isobutylcarbamoyl-vinyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LiCl, 1,8-diazabicyclo<5.4.0>-7-undecene / 1.) THF, benzene, RT, 10 min, 2.) THF, benzene, RT, overnight

2: KOH / ethanol; H₂O / Ambient temperature

3: diphenylphosphorazidate (DPPA), Et₃N / dimethylformamide / 1.) -10 deg C, 2 h, 2.) RT, overnight

With potassium hydroxide; diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.40.364

Reference yield:

: 118741-35-8
(4S,5S)-5-((E)-2-Ethoxycarbonyl-vinyl)-4-isobutyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

: 118741-37-0
(4S,5S)-4-Isobutyl-5-((E)-2-isobutylcarbamoyl-vinyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: KOH / ethanol; H₂O / Ambient temperature

2: diphenylphosphorazidate (DPPA), Et₃N / dimethylformamide / 1.) -10 deg C, 2 h, 2.) RT, overnight

With potassium hydroxide; diphenyl phosphoryl azide; triethylamine; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.40.364