Technology Process of 3',4,4',5'-tetramethoxychalcone
There total 3 articles about 3',4,4',5'-tetramethoxychalcone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl (3,4,5-trimethoxyphenyl) ketone; 4-methoxy-benzaldehyde;
With
sodium hydroxide;
In
methanol;
at 20 ℃;
for 24h;
With
hydrogenchloride; water;
In
methanol;
DOI:10.1016/j.bmc.2009.09.044
- Guidance literature:
-
9-methyl-9H-fluorene-9-carbonyl chloride;
With
tri-tert-butyl phosphine; N-Methyldicyclohexylamine; N-ethyl-N,N-diisopropylamine; bis(dibenzylideneacetone)-palladium(0); catacxium A;
In
1,4-dioxane;
Inert atmosphere;
4-Methoxystyrene; 5-iodo-1,2,3-trimethoxybenzene;
With
N-Methyldicyclohexylamine; catacxium A;
In
1,4-dioxane;
at 95 ℃;
for 40h;
Inert atmosphere;
DOI:10.1021/ol200686h
- Guidance literature:
-
Multi-step reaction with 2 steps
1: aqueous H2SO4
2: benzyl-trimethyl-ammonium hydroxide; aqueous ethanol
With
ethanol; sulfuric acid; N-benzyl-trimethylammonium hydroxide;
DOI:10.1021/ja01554a043
