5-amino-1-(4-fluorophenyl)-4-[3-(2-tert-butyldimethylsilyloxyethyl)benzoyl]pyrazole

Base Information

Chemical Name:5-amino-1-(4-fluorophenyl)-4-[3-(2-tert-butyldimethylsilyloxyethyl)benzoyl]pyrazole
CAS No.:249937-09-5
Molecular Formula:C₂₄H₃₀FN₃O₂Si
Molecular Weight:439.605
Hs Code.:

Synonyms:5-amino-1-(4-fluorophenyl)-4-[3-(2-tert-butyldimethylsilyloxyethyl)benzoyl]pyrazole

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Chemical Property of 5-amino-1-(4-fluorophenyl)-4-[3-(2-tert-butyldimethylsilyloxyethyl)benzoyl]pyrazole

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Technology Process of 5-amino-1-(4-fluorophenyl)-4-[3-(2-tert-butyldimethylsilyloxyethyl)benzoyl]pyrazole

There total 5 articles about 5-amino-1-(4-fluorophenyl)-4-[3-(2-tert-butyldimethylsilyloxyethyl)benzoyl]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 249937-07-3
[2‐(3‐bromophenyl)ethoxy](tert‐butyl)dimethylsilane

: 249937-08-4
5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbothioic acid S-pyridin-2-yl ester

: 249937-09-5
5-amino-1-(4-fluorophenyl)-4-[3-(2-tert-butyldimethylsilyloxyethyl)benzoyl]pyrazole

Guidance literature:: [2‐(3‐bromophenyl)ethoxy](tert‐butyl)dimethylsilane; With iodine; magnesium; In tetrahydrofuran; for 3h; Heating / reflux;

5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbothioic acid S-pyridin-2-yl ester; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 187949-90-2
5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

: 249937-09-5
5-amino-1-(4-fluorophenyl)-4-[3-(2-tert-butyldimethylsilyloxyethyl)benzoyl]pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: PPh₃ / acetonitrile / 16 h / 20 °C

2.1: Mg / tetrahydrofuran / 3 h / Heating

2.2: 1.20 g / tetrahydrofuran / 16 h / 20 °C

With magnesium; triphenylphosphine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm050736c

Reference yield:

: 1878-67-7
3-Bromophenylacetic acid

: 249937-09-5
5-amino-1-(4-fluorophenyl)-4-[3-(2-tert-butyldimethylsilyloxyethyl)benzoyl]pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 9.0 g / diborane / tetrahydrofuran / 16 h / 20 °C

2.1: 6.0 g / 4-(dimethylamino)pyridine; Et₃N / CH₂Cl₂ / 1 h

3.1: Mg / tetrahydrofuran / 3 h / Heating

3.2: 1.20 g / tetrahydrofuran / 16 h / 20 °C

With dmap; magnesium; triethylamine; diborane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm050736c