C₁₄H₁₆FN₃O₃

Base Information

• Chemical Name: C₁₄H₁₆FN₃O₃
• CAS No.: 1314874-86-6
• Molecular Formula: C₁₄H₁₆FN₃O₃
• Molecular Weight: 293.298
• Mol file: 1314874-86-6.mol

Synonyms:C₁₄H₁₆FN₃O₃

Chemical Property of C₁₄H₁₆FN₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₁₄H₁₆FN₃O₃

There total 3 articles about C₁₄H₁₆FN₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + C12H13BrFN3O (1314874-85-5) → C14H16FN3O3 (1314874-86-6)

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; at 125 ℃; for 16h; under 15001.5 Torr; Inert atmosphere;

Reference yield:

3,5-dibromo-1-(propan-2-yl)-1H-1,2,4-triazole (1240567-67-2) → C14H16FN3O3 (1314874-86-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

2: 1,3-bis-(diphenylphosphino)propane / palladium diacetate / tetrahydrofuran / 16 h / 125 °C / 15001.5 Torr / Inert atmosphere

With 1,3-bis-(diphenylphosphino)propane; potassium carbonate; palladium diacetate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

4-fluoro-2-methylphenol (452-72-2) → C14H16FN3O3 (1314874-86-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

2: 1,3-bis-(diphenylphosphino)propane / palladium diacetate / tetrahydrofuran / 16 h / 125 °C / 15001.5 Torr / Inert atmosphere

With 1,3-bis-(diphenylphosphino)propane; potassium carbonate; palladium diacetate; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

methanol

carbon monoxide

C₁₂H₁₃BrFN₃O

4-fluoro-2-methylphenol

Downstream raw materials:

C₁₃H₁₄FN₃O₃