1-(2-fluoro-5-isopropoxy)benzyl-6,7-dimethoxyisoquinoline-4-carcoxylic acid ethyl ester

Base Information

Chemical Name:1-(2-fluoro-5-isopropoxy)benzyl-6,7-dimethoxyisoquinoline-4-carcoxylic acid ethyl ester
CAS No.:798563-65-2
Molecular Formula:C₂₄H₂₆FNO₅
Molecular Weight:427.473
Hs Code.:

Synonyms:1-(2-fluoro-5-isopropoxy)benzyl-6,7-dimethoxyisoquinoline-4-carcoxylic acid ethyl ester

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Chemical Property of 1-(2-fluoro-5-isopropoxy)benzyl-6,7-dimethoxyisoquinoline-4-carcoxylic acid ethyl ester

Chemical Property:

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Technology Process of 1-(2-fluoro-5-isopropoxy)benzyl-6,7-dimethoxyisoquinoline-4-carcoxylic acid ethyl ester

There total 11 articles about 1-(2-fluoro-5-isopropoxy)benzyl-6,7-dimethoxyisoquinoline-4-carcoxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1344688-85-2
C₂₄H₂₈FNO₅

: 798563-65-2
1-(2-fluoro-5-isopropoxy)benzyl-6,7-dimethoxyisoquinoline-4-carcoxylic acid ethyl ester

Guidance literature:: With sulfur; at 165 ℃; neat (no solvent);
DOI:10.1016/j.bmcl.2011.09.009

Reference yield:

: 93-17-4
3,4-dimethoxyphenylacetonitrile

: 798563-65-2
1-(2-fluoro-5-isopropoxy)benzyl-6,7-dimethoxyisoquinoline-4-carcoxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium / ethanol; toluene

1.2: 80 °C

2.1: hydrogenchloride; palladium on activated charcoal; hydrogen / ethanol / 2585.81 Torr

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane

4.1: phosphorus pentachloride / dichloromethane

5.1: sulfur / 165 °C / neat (no solvent)

With hydrogenchloride; phosphorus pentachloride; palladium on activated charcoal; hydrogen; sodium; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sulfur; triethylamine; In ethanol; dichloromethane; toluene; 4.1: Bischler-Napieralski reaction;
DOI:10.1016/j.bmcl.2011.09.009

Reference yield:

: 36848-69-8
ethyl 2-cyano-2-(3,4-dimethoxyphenyl)acetate

: 798563-65-2
1-(2-fluoro-5-isopropoxy)benzyl-6,7-dimethoxyisoquinoline-4-carcoxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; palladium on activated charcoal; hydrogen / ethanol / 2585.81 Torr

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane

3: phosphorus pentachloride / dichloromethane

4: sulfur / 165 °C / neat (no solvent)

With hydrogenchloride; phosphorus pentachloride; palladium on activated charcoal; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sulfur; triethylamine; In ethanol; dichloromethane; 3: Bischler-Napieralski reaction;
DOI:10.1016/j.bmcl.2011.09.009