3-[4-(tert-butyldimethylsilanyloxy)phenyl]propionic acid tert-butyl ester

Base Information

Chemical Name:3-[4-(tert-butyldimethylsilanyloxy)phenyl]propionic acid tert-butyl ester
CAS No.:590402-33-8
Molecular Formula:C₁₉H₃₂O₃Si
Molecular Weight:336.547
Hs Code.:

Synonyms:3-[4-(tert-butyldimethylsilanyloxy)phenyl]propionic acid tert-butyl ester

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Chemical Property of 3-[4-(tert-butyldimethylsilanyloxy)phenyl]propionic acid tert-butyl ester

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Technology Process of 3-[4-(tert-butyldimethylsilanyloxy)phenyl]propionic acid tert-butyl ester

There total 3 articles about 3-[4-(tert-butyldimethylsilanyloxy)phenyl]propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 51458-31-2
3-(4-hydroxyphenyl)propionic acid tert-butyl ester

: 590402-33-8
3-[4-(tert-butyldimethylsilanyloxy)phenyl]propionic acid tert-butyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 8h;
DOI:10.1039/b302239k

Reference yield: 69.0%

: 67963-68-2
t-butyldimethylsilyl-4-bromophenol

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 590402-33-8
3-[4-(tert-butyldimethylsilanyloxy)phenyl]propionic acid tert-butyl ester

Guidance literature:: With bis(cyclopentadienyl)titanium dichloride; manganese; chloro-trimethyl-silane; triphenylphosphine; nickel dichloride; In tetrahydrofuran; at 50 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jo402626u

Reference yield:

: 501-97-3
4-hydroxyphenylpropionic acid

: 590402-33-8
3-[4-(tert-butyldimethylsilanyloxy)phenyl]propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: carbonyldiimidazole / dimethylformamide / 48 h / 40 °C

1.2: 65 percent / DBU / dimethylformamide / 2 h / 65 °C

2.1: 79 percent / DMAP; Et₃N / CH₂Cl₂ / 8 h / 20 °C

With dmap; triethylamine; 1,1'-carbonyldiimidazole; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b302239k