(S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-2-methylbutan-1-ol

Base Information

Chemical Name:(S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-2-methylbutan-1-ol
CAS No.:1260511-77-0
Molecular Formula:C₂₅H₃₄ClNO₅S
Molecular Weight:496.068
Hs Code.:

Synonyms:(S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-2-methylbutan-1-ol

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Chemical Property of (S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-2-methylbutan-1-ol

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Technology Process of (S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-2-methylbutan-1-ol

There total 5 articles about (S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-2-methylbutan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260511-66-7
2-(Methoxymethoxy)-5-methylbenzenethiol

: 1260511-62-3
(S)-4-(4-bromo-2-chlorophenyl)-2-t-butoxycarbonylamino-2-methylbutan-1-ol

: 1260511-77-0
(S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-2-methylbutan-1-ol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In 1,4-dioxane; for 3h; Reflux; Inert atmosphere;

Reference yield:

: 1260511-60-1
methyl (S)-4-(4-bromo-2-chlorophenyl)-2-t-butoxycarbonylamino-2-methyl butyrate

: 1260511-77-0
(S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-2-methylbutan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: lithium borohydride; ethanol / tetrahydrofuran / 2 h / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 1,4-dioxane / 3 h / Reflux; Inert atmosphere

With lithium borohydride; ethanol; N-ethyl-N,N-diisopropylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 916516-91-1
4-bromo-2-chloro-1-(2-iodoethyl)benzene

: 1260511-77-0
(S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-2-methylbutan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 - 0 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2.2: 1 h / 20 °C

3.1: lithium borohydride; ethanol / tetrahydrofuran / 2 h / Cooling with ice

4.1: N-ethyl-N,N-diisopropylamine / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 1,4-dioxane / 3 h / Reflux; Inert atmosphere

With hydrogenchloride; lithium borohydride; n-butyllithium; ethanol; N-ethyl-N,N-diisopropylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; 1,4-dioxane; hexane;