2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-trimethylbenzenesulfonate

Base Information

Chemical Name:2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-trimethylbenzenesulfonate
CAS No.:1256497-70-7
Molecular Formula:C₃₁H₄₅N₃O₆SSi
Molecular Weight:615.866
Hs Code.:

Synonyms:2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-trimethylbenzenesulfonate

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Chemical Property of 2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-trimethylbenzenesulfonate

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Technology Process of 2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-trimethylbenzenesulfonate

There total 7 articles about 2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-trimethylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 773-64-8
2-mesitylenesulphonyl chloride

: 1256497-69-4
2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ol

: 1256497-70-7
2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-trimethylbenzenesulfonate

Guidance literature:: With N,N,N'N'-tetramethyl-1,3-propanediamine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 89031-84-5
3-(tert-butyldimethylsilyloxy)propyl bromide

: 1256497-70-7
2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-trimethylbenzenesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 2.5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride; lithium chloride / tetrahydrofuran / 0.67 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

4.2: 6 h / 80 °C

5.1: methanol / 8 h / 75 °C

6.1: N,N,N'N'-tetramethyl-1,3-propanediamine / tetrahydrofuran / 3 h / 20 °C

With sodium tetrahydroborate; N,N,N'N'-tetramethyl-1,3-propanediamine; sodium hydride; potassium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1256497-65-0
4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzaldehyde

: 1256497-70-7
2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-trimethylbenzenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 2.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride; lithium chloride / tetrahydrofuran / 0.67 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

3.2: 6 h / 80 °C

4.1: methanol / 8 h / 75 °C

5.1: N,N,N'N'-tetramethyl-1,3-propanediamine / tetrahydrofuran / 3 h / 20 °C

With sodium tetrahydroborate; N,N,N'N'-tetramethyl-1,3-propanediamine; sodium hydride; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;