2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ol

Base Information

Chemical Name:2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ol
CAS No.:1256497-69-4
Molecular Formula:C₂₂H₃₅N₃O₄Si
Molecular Weight:433.623
Hs Code.:

Synonyms:2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ol

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Chemical Property of 2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ol

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Technology Process of 2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ol

There total 7 articles about 2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 593-85-1,90332-86-8,3425-08-9
guanidine carbonate

: 1256497-68-3
methyl 2-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-3-oxobutanoate

: 1256497-69-4
2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ol

Guidance literature:: In methanol; at 75 ℃; for 8h;

Reference yield:

: 1256497-68-3
methyl 2-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-3-oxobutanoate

: 593-85-1,90332-86-8,3425-08-9
diguanidine carbonate

: 1256497-69-4
2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ol

Guidance literature:: In methanol; at 75 ℃; for 8h;

Reference yield:

: 89031-84-5
3-(tert-butyldimethylsilyloxy)propyl bromide

: 1256497-69-4
2-amino-5-{4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 2.5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride; lithium chloride / tetrahydrofuran / 0.67 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

4.2: 6 h / 80 °C

5.1: methanol / 8 h / 75 °C

With sodium tetrahydroborate; sodium hydride; potassium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;