tert-butyl (2-((2-(cyclohex-1-en-1-ylamino)-2-oxo-1-(4-(trifluoromethyl)phenyl)ethyl)(prop-2-yn-1-yl)carbamoyl)-4-iodophenyl)carbamate

Base Information

Chemical Name:tert-butyl (2-((2-(cyclohex-1-en-1-ylamino)-2-oxo-1-(4-(trifluoromethyl)phenyl)ethyl)(prop-2-yn-1-yl)carbamoyl)-4-iodophenyl)carbamate
CAS No.:1383960-00-6
Molecular Formula:C₃₀H₃₁F₃IN₃O₄
Molecular Weight:681.494
Hs Code.:

Synonyms:tert-butyl (2-((2-(cyclohex-1-en-1-ylamino)-2-oxo-1-(4-(trifluoromethyl)phenyl)ethyl)(prop-2-yn-1-yl)carbamoyl)-4-iodophenyl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (2-((2-(cyclohex-1-en-1-ylamino)-2-oxo-1-(4-(trifluoromethyl)phenyl)ethyl)(prop-2-yn-1-yl)carbamoyl)-4-iodophenyl)carbamate

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Technology Process of tert-butyl (2-((2-(cyclohex-1-en-1-ylamino)-2-oxo-1-(4-(trifluoromethyl)phenyl)ethyl)(prop-2-yn-1-yl)carbamoyl)-4-iodophenyl)carbamate

There total 1 articles about tert-butyl (2-((2-(cyclohex-1-en-1-ylamino)-2-oxo-1-(4-(trifluoromethyl)phenyl)ethyl)(prop-2-yn-1-yl)carbamoyl)-4-iodophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 1121-57-9
1-isocyanocyclohexene

: 2450-71-7
Propargylamine

: 445479-86-7
2-[N-(tert-Butyloxycarbonyl)amino]-5-iodobenzoic acid

: 1383960-00-6
tert-butyl (2-((2-(cyclohex-1-en-1-ylamino)-2-oxo-1-(4-(trifluoromethyl)phenyl)ethyl)(prop-2-yn-1-yl)carbamoyl)-4-iodophenyl)carbamate

Guidance literature:: 4-Trifluoromethylbenzaldehyde; Propargylamine; In methanol; at 20 ℃; for 0.5h;

1-isocyanocyclohexene; 2-[N-(tert-Butyloxycarbonyl)amino]-5-iodobenzoic acid; With scandium tris(trifluoromethanesulfonate); In methanol; at 20 ℃; for 18h;
DOI:10.1021/ja304213w

Reference yield: 48.0%

: 1383960-00-6
tert-butyl (2-((2-(cyclohex-1-en-1-ylamino)-2-oxo-1-(4-(trifluoromethyl)phenyl)ethyl)(prop-2-yn-1-yl)carbamoyl)-4-iodophenyl)carbamate

: 1383960-08-4
7-iodo-4-(prop-2-yn-1-yl)-3-(4-(trifluoromethyl)phenyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Guidance literature:: With hydrogenchloride; acetyl chloride; In methanol; at 20 ℃; for 18h;
DOI:10.1021/ja304213w

Reference yield:

: 1383960-00-6
tert-butyl (2-((2-(cyclohex-1-en-1-ylamino)-2-oxo-1-(4-(trifluoromethyl)phenyl)ethyl)(prop-2-yn-1-yl)carbamoyl)-4-iodophenyl)carbamate

: 1383959-73-6
7-([1,1'-biphen-3-yl]carbonyl)-3-(4-methoxyphenyl)-4-(prop-2-yn-1-yl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; acetyl chloride / methanol / 18 h / 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; methoxybenzene / 2 h / 80 °C / 760.05 Torr

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; methoxybenzene; acetyl chloride; In methanol;
DOI:10.1021/ja304213w