4-chloro-2-(o-chlorobenzoyl)-N^α-(benzyloxycarbonyl)glycinanilide

Base Information

• Chemical Name: 4-chloro-2-(o-chlorobenzoyl)-N^α-(benzyloxycarbonyl)glycinanilide
• CAS No.: 29176-39-4
• Molecular Formula: C₂₃H₁₈Cl₂N₂O₄
• Molecular Weight: 457.313
• Mol file: 29176-39-4.mol

Synonyms:4-chloro-2-(o-chlorobenzoyl)-N^α-(benzyloxycarbonyl)glycinanilide

Chemical Property of 4-chloro-2-(o-chlorobenzoyl)-N^α-(benzyloxycarbonyl)glycinanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-2-(o-chlorobenzoyl)-N^α-(benzyloxycarbonyl)glycinanilide

There total 4 articles about 4-chloro-2-(o-chlorobenzoyl)-N^α-(benzyloxycarbonyl)glycinanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(Benzyloxycarbonyl)glycine (1138-80-3) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3,53960-29-5) → 4-chloro-2-(o-chlorobenzoyl)-Nα-(benzyloxycarbonyl)glycinanilide (29176-39-4)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; thionyl chloride; at -8 - -5 ℃;

Reference yield:

N-(Benzyloxycarbonyl)glycine (1138-80-3) → 4-chloro-2-(o-chlorobenzoyl)-Nα-(benzyloxycarbonyl)glycinanilide (29176-39-4)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / hexamethylphosphoric acid triamide; acetonitrile / 0.17 h / -5 °C

2: hexamethylphosphoric acid triamide; acetonitrile / Ambient temperature

With thionyl chloride; In N,N,N,N,N,N-hexamethylphosphoric triamide; acetonitrile;

DOI:10.1021/jm00133a006

Reference yield:

N-(benzyloxycarbonyl)glycyl chloride (15050-24-5) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3,53960-29-5) → 4-chloro-2-(o-chlorobenzoyl)-Nα-(benzyloxycarbonyl)glycinanilide (29176-39-4)

Guidance literature:

In N,N,N,N,N,N-hexamethylphosphoric triamide; acetonitrile; Yield given; Ambient temperature;

DOI:10.1021/jm00133a006

upstream raw materials:

N-(Benzyloxycarbonyl)glycine

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone

N-(benzyloxycarbonyl)glycyl chloride

Downstream raw materials:

4-chloro-2-(o-chlorobenzoyl)-N-glycinanilide hydrobromide

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(benzyloxycarbonyl)glycinanilide

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(phthalylglycyl)glycinanilide

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(chloroacetyl)glycinanilide