ethyl 1-cyclohexyl-4,5-dioxo-2-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate

Base Information

• Chemical Name: ethyl 1-cyclohexyl-4,5-dioxo-2-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate
• CAS No.: 1253903-18-2
• Molecular Formula: C₁₉H₂₁NO₄
• Molecular Weight: 327.38

Synonyms:ethyl 1-cyclohexyl-4,5-dioxo-2-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate

Chemical Property of ethyl 1-cyclohexyl-4,5-dioxo-2-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate

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Technology Process of ethyl 1-cyclohexyl-4,5-dioxo-2-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate

There total 1 articles about ethyl 1-cyclohexyl-4,5-dioxo-2-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

oxalyl dichloride (79-37-8) + ethyl 3-oxo-3-phenylpropionate (94-02-0) + cyclohexylamine (108-91-8,157973-60-9) → ethyl 1-cyclohexyl-4,5-dioxo-2-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate (1253903-18-2)

Guidance literature:

ethyl 3-oxo-3-phenylpropionate; cyclohexylamine; With acetic acid; In ethanol; for 2h; Reflux;

oxalyl dichloride; In chloroform; for 2h; Reflux;

DOI:10.1134/S1070428010080105

Reference yield: 78.0%

dimedone (3471-13-4) + ethyl 1-cyclohexyl-4,5-dioxo-2-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate (1253903-18-2) + malononitrile (109-77-3) → ethyl 2-amino-7,7-dimethyl-2',5-dioxo-5'-phenyl-3-cyano-1'-cyclohexyl-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-pyrrole]-4'-carboxylate (1335103-49-5)

Guidance literature:

With triethylamine; In benzene; for 2h; Reflux;

DOI:10.1134/S1070428011080082

Reference yield: 78.0%

ethyl 1-cyclohexyl-4,5-dioxo-2-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate (1253903-18-2) + 9-bromo-4,4-dimethyl-2-(naphthalen-1-yl)-4,5-dihydropyrrolo[2,3,4-kl]acridin-1(2H)-one (117358-76-6,117466-14-5,188829-49-4) → ethyl 1'-cyclohexyl-10,10-dimethyl-2',8-dioxo-5'-phenyl-1',2',9,10,11,12-hexahydro-8H-spiro[benzo[c]acridine-7,3'-pyrrole]-4'-carboxylate (1253903-37-5)

Guidance literature:

In m-xylene; Reflux;

DOI:10.1134/S1070428010080105

upstream raw materials:

oxalyl dichloride

ethyl 3-oxo-3-phenylpropionate

cyclohexylamine

Downstream raw materials:

ethyl 1'-cyclohexyl-10,10-dimethyl-2',8-dioxo-5'-phenyl-1',2',9,10,11,12-hexahydro-8H-spiro[benzo[c]acridine-7,3'-pyrrole]-4'-carboxylate

ethyl 2-amino-7,7-dimethyl-2',5-dioxo-5'-phenyl-3-cyano-1'-cyclohexyl-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-pyrrole]-4'-carboxylate

3-methyl 4'-ethyl 2-amino-7,7-dimethyl-2',5-dioxo-5'-phenyl-1'-cyclohexyl-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-pyrrole]-3,4'-dicarboxylate

ethyl 1'-cyclohexyl-2,10,12-trioxo-5'-phenyl-5-(4-tolyl)-1',2',10,12-tetrahydro-5H-spiro{diindeno[1,2-b:2',1'-e]pyridine-11,3'-pyrrole}-4'-carboxylate

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