(2R,6S)-1-benzyl-2-[(4S)-2,2-dimethyl[1,3 ]dioxolan-4-yl]-6-isopropylpiperidin-4-one

Base Information

• Chemical Name: (2R,6S)-1-benzyl-2-[(4S)-2,2-dimethyl[1,3 ]dioxolan-4-yl]-6-isopropylpiperidin-4-one
• CAS No.: 211228-88-5
• Molecular Formula: C₂₀H₂₉NO₃
• Molecular Weight: 331.455

Synonyms:(2R,6S)-1-benzyl-2-[(4S)-2,2-dimethyl[1,3 ]dioxolan-4-yl]-6-isopropylpiperidin-4-one

Chemical Property of (2R,6S)-1-benzyl-2-[(4S)-2,2-dimethyl[1,3 ]dioxolan-4-yl]-6-isopropylpiperidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,6S)-1-benzyl-2-[(4S)-2,2-dimethyl[1,3 ]dioxolan-4-yl]-6-isopropylpiperidin-4-one

There total 2 articles about (2R,6S)-1-benzyl-2-[(4S)-2,2-dimethyl[1,3 ]dioxolan-4-yl]-6-isopropylpiperidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

methanol (67-56-1) + isobutylidenebenzylamine (22483-21-2) + (3E)-4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)]but-3-en-2-one (64482-41-3) → C10H18O4 (333422-01-8) + (2R,6S)-1-benzyl-2-[(4S)-2,2-dimethyl[1,3 ]dioxolan-4-yl]-6-isopropylpiperidin-4-one (211228-88-5) + (2S,6R)-1-benzyl-2-[(4S)-2,2-dimethyl[1,3 ]dioxolan-4-yl]-6-isopropylpiperidin-4-one

Guidance literature:

With acetic acid; at 0 - 20 ℃; optical yield given as %de; diastereoselective reaction;

Reference yield: 27.0%

methanol (67-56-1) + (3E)-4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)]but-3-en-2-one (64482-41-3) + isobutyraldehyde (78-84-2) + benzylamine (100-46-9) → C10H18O4 (333422-01-8) + (2R,6S)-1-benzyl-2-[(4S)-2,2-dimethyl[1,3 ]dioxolan-4-yl]-6-isopropylpiperidin-4-one (211228-88-5) + (2S,6R)-1-benzyl-2-[(4S)-2,2-dimethyl[1,3 ]dioxolan-4-yl]-6-isopropylpiperidin-4-one

Guidance literature:

With acetic acid; at 0 - 20 ℃; optical yield given as %de; diastereoselective reaction;

Reference yield: 61.0%

(2R,6S)-1-benzyl-2-[(4S)-2,2-dimethyl[1,3 ]dioxolan-4-yl]-6-isopropylpiperidin-4-one (211228-88-5) → (2R,6S)-1-benzyl-2-[(1S)-1,2-dihydroxyethyl]-6-isopropylpiperidin-4-one (211229-22-0)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 4h;

upstream raw materials:

methanol

isobutylidenebenzylamine

(3E)-4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)]but-3-en-2-one

isobutyraldehyde

Downstream raw materials:

C₁₈H₂₇NO₃

(2R,4R,6S)-1-benzyl-2-[(4S)-2,2-dimethyl-[1,3]dioxolane-4-yl]-6-isopropylpiperidin-4-ol

(2R,4S,6S)-1-benzyl-2-[(4S)-2,2-dimethyl[1,3]dioxolan-4-yl]-6-isopropylpiperidin-4-ol

(2R,6S)-1-benzyl-2-[(1S)-1,2-dihydroxyethyl]-6-isopropylpiperidin-4-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

✦Write with AI

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 211228-88-5 (2R,6S)-1-benzyl-2-[(4S)-2,2-dimethyl[1,3 ]dioxolan-4-yl]-6-isopropylpiperidin-4-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send