methyl 3-bromo-6-(2,2-dimethylpropionylamino)-2-(2-pyrrolidin-2-yl-ethyl)-benzoate

Base Information

Chemical Name:methyl 3-bromo-6-(2,2-dimethylpropionylamino)-2-(2-pyrrolidin-2-yl-ethyl)-benzoate
CAS No.:1411983-03-3
Molecular Formula:C₁₉H₂₇BrN₂O₃
Molecular Weight:411.339
Hs Code.:

Synonyms:methyl 3-bromo-6-(2,2-dimethylpropionylamino)-2-(2-pyrrolidin-2-yl-ethyl)-benzoate

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Chemical Property of methyl 3-bromo-6-(2,2-dimethylpropionylamino)-2-(2-pyrrolidin-2-yl-ethyl)-benzoate

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Technology Process of methyl 3-bromo-6-(2,2-dimethylpropionylamino)-2-(2-pyrrolidin-2-yl-ethyl)-benzoate

There total 9 articles about methyl 3-bromo-6-(2,2-dimethylpropionylamino)-2-(2-pyrrolidin-2-yl-ethyl)-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1411983-04-4
tert butyl 2-{2-[6-bromo-3-(2,2-dimethylpropionylamino)-2-methoxycarbonyl-phenyl]-ethyl}-pyrrolidine-1-carboxylate

: 1411983-03-3
methyl 3-bromo-6-(2,2-dimethylpropionylamino)-2-(2-pyrrolidin-2-yl-ethyl)-benzoate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1411983-03-3
methyl 3-bromo-6-(2,2-dimethylpropionylamino)-2-(2-pyrrolidin-2-yl-ethyl)-benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydrogencarbonate / ethyl acetate; water

2: pyridine / dichloromethane / 1 h / Cooling with ice

3: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 95 °C / Inert atmosphere

4: hydrogen / palladium 10% on activated carbon / ethanol / 4 h

5: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

6: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With pyridine; N-Bromosuccinimide; hydrogen; sodium hydrogencarbonate; trifluoroacetic acid; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 316141-37-4
(R)-2-ethynyl-1-pyrrolidinecarboxylic acid,1,1-dimethylethyl ester

: 1411983-03-3
methyl 3-bromo-6-(2,2-dimethylpropionylamino)-2-(2-pyrrolidin-2-yl-ethyl)-benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - -30 °C / Inert atmosphere

1.2: -30 - -10 °C

2.1: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 95 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h

4.1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With N-Bromosuccinimide; n-butyllithium; hydrogen; trifluoroacetic acid; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;