tert butyl 2-{2-[6-bromo-3-(2,2-dimethylpropionylamino)-2-methoxycarbonyl-phenyl]-ethyl}-pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert butyl 2-{2-[6-bromo-3-(2,2-dimethylpropionylamino)-2-methoxycarbonyl-phenyl]-ethyl}-pyrrolidine-1-carboxylate
CAS No.:1411983-04-4
Molecular Formula:C₂₄H₃₅BrN₂O₅
Molecular Weight:511.456
Hs Code.:

Synonyms:tert butyl 2-{2-[6-bromo-3-(2,2-dimethylpropionylamino)-2-methoxycarbonyl-phenyl]-ethyl}-pyrrolidine-1-carboxylate

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Chemical Property of tert butyl 2-{2-[6-bromo-3-(2,2-dimethylpropionylamino)-2-methoxycarbonyl-phenyl]-ethyl}-pyrrolidine-1-carboxylate

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Technology Process of tert butyl 2-{2-[6-bromo-3-(2,2-dimethylpropionylamino)-2-methoxycarbonyl-phenyl]-ethyl}-pyrrolidine-1-carboxylate

There total 8 articles about tert butyl 2-{2-[6-bromo-3-(2,2-dimethylpropionylamino)-2-methoxycarbonyl-phenyl]-ethyl}-pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1411983-05-5
tert-butyl 2-{2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl]-ethyl}-pyrrolidine-1-carboxylate

: 1411983-04-4
tert butyl 2-{2-[6-bromo-3-(2,2-dimethylpropionylamino)-2-methoxycarbonyl-phenyl]-ethyl}-pyrrolidine-1-carboxylate

Guidance literature:: With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1411983-04-4
tert butyl 2-{2-[6-bromo-3-(2,2-dimethylpropionylamino)-2-methoxycarbonyl-phenyl]-ethyl}-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / ethyl acetate; water

2: pyridine / dichloromethane / 1 h / Cooling with ice

3: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 95 °C / Inert atmosphere

4: hydrogen / palladium 10% on activated carbon / ethanol / 4 h

5: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

With pyridine; N-Bromosuccinimide; hydrogen; sodium hydrogencarbonate; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 316141-37-4
(R)-2-ethynyl-1-pyrrolidinecarboxylic acid,1,1-dimethylethyl ester

: 1411983-04-4
tert butyl 2-{2-[6-bromo-3-(2,2-dimethylpropionylamino)-2-methoxycarbonyl-phenyl]-ethyl}-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - -30 °C / Inert atmosphere

1.2: -30 - -10 °C

2.1: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 95 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h

4.1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

With N-Bromosuccinimide; n-butyllithium; hydrogen; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;