(R)-2-(methoxymethylcarbamoyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester

Base Information

• Chemical Name: (R)-2-(methoxymethylcarbamoyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester
• CAS No.: 1586810-40-3
• Molecular Formula: C₁₇H₃₁N₃O₆
• Molecular Weight: 373.45

Synonyms:(R)-2-(methoxymethylcarbamoyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester

Chemical Property of (R)-2-(methoxymethylcarbamoyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester

Chemical Property:

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Technology Process of (R)-2-(methoxymethylcarbamoyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester

There total 1 articles about (R)-2-(methoxymethylcarbamoyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(R)-piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester (173774-48-6) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → (R)-2-(methoxymethylcarbamoyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester (1586810-40-3)

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl acetamide; for 18h;

Reference yield: 80.0%

(R)-2-(methoxymethylcarbamoyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester (1586810-40-3) + phenylmagnesium chloride (100-59-4) → (R)-2-benzoylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester (1589081-62-8)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 4h;

Reference yield: 64.0%

(R)-2-(methoxymethylcarbamoyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester (1586810-40-3) + 4-flourophenylmagnesium bromide (352-13-6) → (R)-2-(4-fluorobenzoyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester (1589081-66-2)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 20 ℃; for 4h;

upstream raw materials:

(R)-piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester

N,O-dimethylhydroxylamine*hydrochloride

Downstream raw materials:

(R)-2-(hydroxyphenylmethyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester

(R)-2-(fluorophenylmethyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester

(R)-2-[(4-fluorophenyl)hydroxymethyl]piperazine-1,4-dicarboxylic acid di-tert-butyl ester

(R)-2-benzoylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester

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