4-[1-(4-hydroxyphenyl)cyclobutyl]phenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 4-[1-(4-hydroxyphenyl)cyclobutyl]phenyl trifluoromethanesulfonate
• CAS No.: 1358755-49-3
• Molecular Formula: C₁₇H₁₅F₃O₄S
• Molecular Weight: 372.365
• Mol file: 1358755-49-3.mol

Synonyms:4-[1-(4-hydroxyphenyl)cyclobutyl]phenyl trifluoromethanesulfonate

Chemical Property of 4-[1-(4-hydroxyphenyl)cyclobutyl]phenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[1-(4-hydroxyphenyl)cyclobutyl]phenyl trifluoromethanesulfonate

There total 2 articles about 4-[1-(4-hydroxyphenyl)cyclobutyl]phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-cyclobutane-1,1-diyldiphenol (951670-96-5) + trifluoromethylsulfonic anhydride (358-23-6) → 4-[1-(4-hydroxyphenyl)cyclobutyl]phenyl trifluoromethanesulfonate (1358755-49-3)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

phenol (108-95-2,27073-41-2) → 4-[1-(4-hydroxyphenyl)cyclobutyl]phenyl trifluoromethanesulfonate (1358755-49-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 72 h / 40 °C

2: pyridine / dichloromethane / 0 - 20 °C

With pyridine; hydrogenchloride; In dichloromethane;

Reference yield:

methanol (67-56-1) + 4-[1-(4-hydroxyphenyl)cyclobutyl]phenyl trifluoromethanesulfonate (1358755-49-3) + carbon monoxide (201230-82-2) → methyl 4-[1-(4-hydroxyphenyl)cyclobutyl]benzoate (951670-98-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; at 50 ℃; for 16h;

upstream raw materials:

4,4'-cyclobutane-1,1-diyldiphenol

trifluoromethylsulfonic anhydride

phenol

Downstream raw materials:

methyl 4-[1-(4-hydroxyphenyl)cyclobutyl]benzoate