CAS No.60-80-0,Antipyrine Suppliers,MSDS download

Products Categories

Pharmaceutical (242)
Organic Chemicals (45)
Others (10)
Reagent (7)
Plant Extract (3)
Basic Inorganic Chemicals (2)
Materials (2)

Basic Information

Molecular Structure:
CAS No.:	60-80-0
Name:	Antipyrine
Article Data:	66

Formula:	C₁₁H₁₂N₂O
Molecular Weight:	188.229
Synonyms:	Antipyrine(8CI);1,5-Dimethyl-2-phenyl-1,2-dihydropyrazol-3-one;2,3-Dimethyl-1-phenyl-3-pyrazolin-5-one;2,3-Dimethyl-1-phenyl-5-pyrazolone;Azophen;Azophene;Dentigoa N;Dimethyloxychinizin;Fenazone;Methozin;NSC7945;Oxydimethylquinazine;Parodyne;Phenazon;Phenazone;Phenazone(pharmaceutical);Phenylon;Phenylone;Pyrazophyl;Sedatin;Sedatine;
EINECS:	200-486-6
Density:	1.156 g/cm³
Melting Point:	109-111 °C(lit.)
Boiling Point:	319 °C at 760 mmHg
Flash Point:	114.8 °C
Solubility:	1000 g/L (20 °C) in water
Appearance:	White Powder
Hazard Symbols:	Xn
Risk Codes:	22-36/37/38
Safety:	26-36-37/39
Transport Information:	UN 3249
PSA:	26.93000
LogP:	1.48440

Synthetic route

: 89-25-8
edaravone

: 77-78-1
dimethyl sulfate

: 60-80-0
antipyrine

Conditions

Conditions	Yield
at 160℃; for 5h;	71%
at 140 - 170℃;

: 948853-49-4
4-(2,3-dimethyl-5-oxo-2,5-dihydro-pyrazol-1-yl)-benzoic acid

: 60-80-0
antipyrine

Conditions

Conditions	Yield
With potassium carbonate In chloroform at 20℃; for 24h; Irradiation; Inert atmosphere;	68%

: 89-25-8
edaravone

: 74-88-4
methyl iodide

: 60-80-0
antipyrine

Conditions

Conditions	Yield
Stage #1: edaravone; methyl iodide In acetonitrile at 120℃; Stage #2: With sodium hydrogencarbonate In water; ethyl acetate	58%
With methanol at 100 - 120℃; im Rohr;
With sodium hydrogencarbonate In acetonitrile
In acetonitrile for 12h; Heating; Sealed tube;

: 67-56-1
methanol

: 89-25-8
edaravone

A: 27349-35-5
5-methoxy-3-methyl-1-phenyl-1H-pyrazole

B: 60-80-0
antipyrine

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran for 20h; Ambient temperature;	A 53% B 14%
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran for 20h; Product distribution; Ambient temperature; various solvents, various ratio of products;

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: 19735-89-8
3-methyl-1-phenylpyrazolin-5(4H)-one

A: 27349-35-5
5-methoxy-3-methyl-1-phenyl-1H-pyrazole

B: 60-80-0
antipyrine

...Expand

: 67-56-1
methanol

: 19735-89-8
3-methyl-1-phenylpyrazolin-5(4H)-one

: 60-80-0
antipyrine

Conditions

Conditions	Yield
With hydrogenchloride at 120℃;
With ethyl bromide at 120℃;

: 74-83-9
methyl bromide

: 19735-89-8
3-methyl-1-phenylpyrazolin-5(4H)-one

: 60-80-0
antipyrine

Conditions

Conditions	Yield
With methoxybenzene
at 132℃;

: 19735-89-8
3-methyl-1-phenylpyrazolin-5(4H)-one

: 74-87-3
methylene chloride

: 60-80-0
antipyrine

Conditions

Conditions	Yield
With methylpyridine at 135℃;
With antipyrine at 135℃;

: 19735-89-8
3-methyl-1-phenylpyrazolin-5(4H)-one

: 80-48-8
methyl p-toluene sulfonate

: 60-80-0
antipyrine

Conditions

Conditions	Yield
at 150 - 160℃;

: 19735-89-8
3-methyl-1-phenylpyrazolin-5(4H)-one

: 77-78-1
dimethyl sulfate

: 60-80-0
antipyrine

Conditions

Conditions	Yield
With xylene at 150℃;
With calcium oxide In methanol

Raw Materials

74-88-4

67-56-1

74-87-3

529-27-1

58-15-1

2436-96-6

622-36-6

141-97-9

Downstream Products

950-81-2

298-12-4

555-16-8

Total:202 Page 1 of 6 1 2 3 4 5 6 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 60-80-0

Consensus Reports

ANTIPYRINE is reported in EPA TSCA Inventory.

Specification

The Antipyrine is an organic compound with the formula C₁₁H₁₂N₂O. The IUPAC name of this chemical is 1,5-dimethyl-2-phenylpyrazol-3-one. With the CAS registry number 60-80-0, it is also named as 3H-pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-2-phenyl-. The product's categories are Intermediates & Fine Chemicals; Pharmaceuticals; Lipid signaling. Besides, it is a white powder, which should be stored in a closed dark and dry place. It is an analgesic and antipyretic.

Physical properties about Antipyrine are: (1)ACD/LogP: 0.27; (2)ACD/LogD (pH 5.5): 0.27; (3)ACD/LogD (pH 7.4): 0.27; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 33.34; (7)ACD/KOC (pH 7.4): 33.34; (8)#H bond acceptors: 3; (9)#Freely Rotating Bonds: 1; (10)Polar Surface Area: 23.55 Å²; (11)Index of Refraction: 1.585; (12)Molar Refractivity: 54.55 cm³; (13)Molar Volume: 162.7 cm³; (14)Polarizability: 21.62×10^-24cm³; (15)Surface Tension: 42.7 dyne/cm; (16)Density: 1.156 g/cm³; (17)Flash Point: 114.8 °C; (18)Enthalpy of Vaporization: 56.05 kJ/mol; (19)Boiling Point: 319 °C at 760 mmHg; (20)Vapour Pressure: 0.000348 mmHg at 25°C.

Preparation: this chemical is formed by reducing diortho- dinitrodiphenyl with sodium amalgam and methyl alcohol, or by heating diphenylene-ortho-dihydrazine with hydrochloric acid to 150 °C. It crystallizes in needles which melt at 156 °C. Potassium permanganate oxidizes it to pyridazine tetracarboxylic acid.

Uses of Antipyrine: it can be used to produce N-methyl-N'-phenyl-hydrazine at temperature of 130 °C. It will need reagent alcoholic KOH-solution.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C2\C=C(/N(N2c1ccccc1)C)C
(2)InChI: InChI=1/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3
(3)InChIKey: VEQOALNAAJBPNY-UHFFFAOYAS
(4)Std. InChI: InChI=1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3
(5)Std. InChIKey: VEQOALNAAJBPNY-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intravenous	525mg/kg (525mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING	Journal of Pharmacology and Experimental Therapeutics. Vol. 39, Pg. 177, 1930.
cat	LDLo	oral	1250mg/kg (1250mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING	Journal of Pharmacology and Experimental Therapeutics. Vol. 39, Pg. 177, 1930.
cat	LDLo	rectal	800mg/kg (800mg/kg)		Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 33, Pg. 10, 1944.
cat	LDLo	subcutaneous	700mg/kg (700mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1304, 1935.
dog	LDLo	oral	500mg/kg (500mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1304, 1935.
frog	LDLo	subcutaneous	2gm/kg (2000mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1304, 1935.
guinea pig	LDLo	oral	1400mg/kg (1400mg/kg)		"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 14, 1959.
guinea pig	LDLo	subcutaneous	1600mg/kg (1600mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION CARDIAC: PULSE RATE	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 186, Pg. 195, 1937.
man	LDLo	unreported	74mg/kg (74mg/kg)		"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse	LD50	intraperitoneal	750mg/kg (750mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 135, Pg. 376, 1962.
mouse	LD50	intravenous	500mg/kg (500mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 686, 1960.
mouse	LD50	oral	1310mg/kg (1310mg/kg)		Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 137, 1956.
mouse	LD50	subcutaneous	1gm/kg (1000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 214, 1967.
rabbit	LDLo	intravenous	600mg/kg (600mg/kg)		"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 14, 1959.
rabbit	LDLo	subcutaneous	1gm/kg (1000mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1304, 1935.
rat	LD50	oral	1705mg/kg (1705mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 401, 1959.
rat	LDLo	subcutaneous	1570mg/kg (1570mg/kg)	AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC CARDIAC: OTHER CHANGES	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 186, Pg. 195, 1937.